TY  - JOUR
AU  - Wang, Yaping
AU  - Wang, Yufan
AU  - Wang, Haiyan
AU  - Ma, Liang
AU  - Eickhoff, Simon B.
AU  - Madsen, Kristoffer Hougaard
AU  - Chu, Congying
AU  - Fan, Lingzhong
TI  - Spatio-molecular profiles shape the human cerebellar hierarchy along the sensorimotor-association axis
JO  - Cell reports
VL  - 43
IS  - 2
SN  - 2211-1247
CY  - [New York, NY]
PB  - Elsevier
M1  - FZJ-2024-01699
SP  - 113770 -
PY  - 2024
AB  - Cerebellar involvement in both motor and non-motor functions manifests in specific regions of the human cerebellum, revealing the functional heterogeneity within it. One compelling theory places the heterogeneity within the cerebellar functional hierarchy along the sensorimotor-association (SA) axis. Despite extensive neuroimaging studies, evidence for the cerebellar SA axis from different modalities and scales was lacking. Thus, we establish a significant link between the cerebellar SA axis and spatio-molecular profiles. Utilizing the gene set variation analysis, we find the intermediate biological principles the significant genes leveraged to scaffold the cerebellar SA axis. Interestingly, we find these spatio-molecular profiles notably associated with neuropsychiatric dysfunction and recent evolution. Furthermore, cerebello-cerebral interactions at genetic and functional connectivity levels mirror the cerebral cortex and cerebellum's SA axis. These findings can provide a deeper understanding of how the human cerebellar SA axis is shaped and its role in transitioning from sensorimotor to association functions.Keywords: CP: Neuroscience; brain evolution; functional hierarchy; gene expression; human cerebellum; neuropsychiatric disorder.
LB  - PUB:(DE-HGF)16
C6  - 38363683
UR  - <Go to ISI:>//WOS:001188121400001
DO  - DOI:10.1016/j.celrep.2024.113770
UR  - https://juser.fz-juelich.de/record/1023460
ER  -