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024 7 _ |a 10.1016/j.celrep.2024.113770
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024 7 _ |a 2639-1856
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024 7 _ |a 10.34734/FZJ-2024-01699
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100 1 _ |a Wang, Yaping
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245 _ _ |a Spatio-molecular profiles shape the human cerebellar hierarchy along the sensorimotor-association axis
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520 _ _ |a Cerebellar involvement in both motor and non-motor functions manifests in specific regions of the human cerebellum, revealing the functional heterogeneity within it. One compelling theory places the heterogeneity within the cerebellar functional hierarchy along the sensorimotor-association (SA) axis. Despite extensive neuroimaging studies, evidence for the cerebellar SA axis from different modalities and scales was lacking. Thus, we establish a significant link between the cerebellar SA axis and spatio-molecular profiles. Utilizing the gene set variation analysis, we find the intermediate biological principles the significant genes leveraged to scaffold the cerebellar SA axis. Interestingly, we find these spatio-molecular profiles notably associated with neuropsychiatric dysfunction and recent evolution. Furthermore, cerebello-cerebral interactions at genetic and functional connectivity levels mirror the cerebral cortex and cerebellum's SA axis. These findings can provide a deeper understanding of how the human cerebellar SA axis is shaped and its role in transitioning from sensorimotor to association functions.Keywords: CP: Neuroscience; brain evolution; functional hierarchy; gene expression; human cerebellum; neuropsychiatric disorder.
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700 1 _ |a Wang, Yufan
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700 1 _ |a Wang, Haiyan
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700 1 _ |a Ma, Liang
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700 1 _ |a Eickhoff, Simon B.
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700 1 _ |a Madsen, Kristoffer Hougaard
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700 1 _ |a Chu, Congying
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700 1 _ |a Fan, Lingzhong
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773 _ _ |a 10.1016/j.celrep.2024.113770
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