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000010235 0247_ $$2DOI$$a10.1007/s00204-010-0551-7
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000010235 084__ $$2WoS$$aToxicology
000010235 1001_ $$0P:(DE-HGF)0$$avan Berlo, D.$$b0
000010235 245__ $$aComparative evaluation of the effects of short-term inhalation exposure to diesel engine exhaust on rat lung and brain
000010235 260__ $$aBerlin$$bSpringer$$c2010
000010235 300__ $$a553 - 562
000010235 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article
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000010235 440_0 $$022482$$aArchives of Toxicology$$v84$$x0340-5761$$y7
000010235 500__ $$aWe thank the members of the Dutch National Vaccine Institute and RIVM, especially John Boere, Daan Leseman and Paul Fokkens, for their experimental assistance. This study is supported by grants from the German Federal Ministry of Environment (BMU), and RIVM, Netherlands (S630111). Sponsors did not participate in study design; collection, analysis, and interpretation of data; and writing of the manuscript.
000010235 520__ $$aCombustion-derived nanoparticles, such as diesel engine exhaust particles, have been implicated in the adverse health effects of particulate air pollution. Recent studies suggest that inhaled nanoparticles may also reach and/or affect the brain. The aim of our study was to comparatively evaluate the effects of short-term diesel engine exhaust (DEE) inhalation exposure on rat brain and lung. After 4 or 18 h recovery from a 2 h nose-only exposure to DEE (1.9 mg/m(3)), the mRNA expressions of heme oxygenase-1 (HO-1), inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), and cytochrome P450 1A1 (CYP1A1) were investigated in lung as well as in pituitary gland, hypothalamus, olfactory bulb, olfactory tubercles, cerebral cortex, and cerebellum. HO-1 protein expression in brain was investigated by immunohistochemistry and ELISA. In the lung, 4 h post-exposure, CYP1A1 and iNOS mRNA levels were increased, while 18 h post-exposure HO-1 was increased. In the pituitary at 4 h post-exposure, both CYP1A1 and HO-1 were increased; HO-1 was also elevated in the olfactory tuberculum at this time point. At 18 h post-exposure, increased expression of HO-1 and COX-2 was observed in cerebral cortex and cerebellum, respectively. Induction of HO-1 protein was not observed after DEE exposure. Bronchoalveolar lavage analysis of inflammatory cell influx, TNF-alpha, and IL-6 indicated that the mRNA expression changes occurred in the absence of lung inflammation. Our study shows that a single, short-term inhalation exposure to DEE triggers region-specific gene expression changes in rat brain to an extent comparable to those observed in the lung.
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000010235 65320 $$2Author$$aDiesel engine exhaust
000010235 65320 $$2Author$$aNanoparticles
000010235 65320 $$2Author$$aBrain
000010235 65320 $$2Author$$aOxidative stress
000010235 65320 $$2Author$$aCYP1A1
000010235 65320 $$2Author$$aHeme oxygenase-1
000010235 650_7 $$2WoSType$$aJ
000010235 7001_ $$0P:(DE-HGF)0$$aAlbrecht, C.$$b1
000010235 7001_ $$0P:(DE-HGF)0$$aKnaapen, Ad.M.$$b2
000010235 7001_ $$0P:(DE-HGF)0$$aFlemming, R.C.$$b3
000010235 7001_ $$0P:(DE-HGF)0$$aGerlofs-Nijland, M.E.$$b4
000010235 7001_ $$0P:(DE-HGF)0$$aKooter, I.M.$$b5
000010235 7001_ $$0P:(DE-Juel1)VDB1208$$aPalomero-Gallagher, N.$$b6$$uFZJ
000010235 7001_ $$0P:(DE-HGF)0$$aBidmon, H.-J.$$b7
000010235 7001_ $$0P:(DE-HGF)0$$avan Schooten, F.-J.$$b8
000010235 7001_ $$0P:(DE-HGF)0$$aKrutmann, J.$$b9
000010235 7001_ $$0P:(DE-HGF)0$$aSchins, R.P.F.$$b10
000010235 773__ $$0PERI:(DE-600)1458459-1$$a10.1007/s00204-010-0551-7$$gVol. 84, p. 553 - 562$$p553 - 562$$q84<553 - 562$$tArchives of toxicology$$v84$$x0340-5761$$y2010
000010235 8567_ $$uhttp://dx.doi.org/10.1007/s00204-010-0551-7
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