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@ARTICLE{vanBerlo:10235,
      author       = {van Berlo, D. and Albrecht, C. and Knaapen, Ad.M. and
                      Flemming, R.C. and Gerlofs-Nijland, M.E. and Kooter, I.M.
                      and Palomero-Gallagher, N. and Bidmon, H.-J. and van
                      Schooten, F.-J. and Krutmann, J. and Schins, R.P.F.},
      title        = {{C}omparative evaluation of the effects of short-term
                      inhalation exposure to diesel engine exhaust on rat lung and
                      brain},
      journal      = {Archives of toxicology},
      volume       = {84},
      issn         = {0340-5761},
      address      = {Berlin},
      publisher    = {Springer},
      reportid     = {PreJuSER-10235},
      pages        = {553 - 562},
      year         = {2010},
      note         = {We thank the members of the Dutch National Vaccine
                      Institute and RIVM, especially John Boere, Daan Leseman and
                      Paul Fokkens, for their experimental assistance. This study
                      is supported by grants from the German Federal Ministry of
                      Environment (BMU), and RIVM, Netherlands (S630111). Sponsors
                      did not participate in study design; collection, analysis,
                      and interpretation of data; and writing of the manuscript.},
      abstract     = {Combustion-derived nanoparticles, such as diesel engine
                      exhaust particles, have been implicated in the adverse
                      health effects of particulate air pollution. Recent studies
                      suggest that inhaled nanoparticles may also reach and/or
                      affect the brain. The aim of our study was to comparatively
                      evaluate the effects of short-term diesel engine exhaust
                      (DEE) inhalation exposure on rat brain and lung. After 4 or
                      18 h recovery from a 2 h nose-only exposure to DEE (1.9
                      mg/m(3)), the mRNA expressions of heme oxygenase-1 (HO-1),
                      inducible nitric oxide synthase (iNOS), cyclooxygenase-2
                      (COX-2), and cytochrome P450 1A1 (CYP1A1) were investigated
                      in lung as well as in pituitary gland, hypothalamus,
                      olfactory bulb, olfactory tubercles, cerebral cortex, and
                      cerebellum. HO-1 protein expression in brain was
                      investigated by immunohistochemistry and ELISA. In the lung,
                      4 h post-exposure, CYP1A1 and iNOS mRNA levels were
                      increased, while 18 h post-exposure HO-1 was increased. In
                      the pituitary at 4 h post-exposure, both CYP1A1 and HO-1
                      were increased; HO-1 was also elevated in the olfactory
                      tuberculum at this time point. At 18 h post-exposure,
                      increased expression of HO-1 and COX-2 was observed in
                      cerebral cortex and cerebellum, respectively. Induction of
                      HO-1 protein was not observed after DEE exposure.
                      Bronchoalveolar lavage analysis of inflammatory cell influx,
                      TNF-alpha, and IL-6 indicated that the mRNA expression
                      changes occurred in the absence of lung inflammation. Our
                      study shows that a single, short-term inhalation exposure to
                      DEE triggers region-specific gene expression changes in rat
                      brain to an extent comparable to those observed in the
                      lung.},
      keywords     = {J (WoSType)},
      cin          = {INM-2},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-2-20090406},
      pnm          = {Funktion und Dysfunktion des Nervensystems (FUEK409) /
                      89571 - Connectivity and Activity (POF2-89571)},
      pid          = {G:(DE-Juel1)FUEK409 / G:(DE-HGF)POF2-89571},
      shelfmark    = {Toxicology},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000278896700004},
      doi          = {10.1007/s00204-010-0551-7},
      url          = {https://juser.fz-juelich.de/record/10235},
}