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001023519 1001_ $$00000-0002-5784-0735$$aSemmler, Carolin$$b0$$eCorresponding author
001023519 245__ $$aPreoperative motor deficits and depressive symptoms predict quality of life in patients with Parkinson’s disease at different time points after surgery for subthalamic stimulation: a retrospective study
001023519 260__ $$a[London]$$bBioMed Central$$c2024
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001023519 520__ $$aAbstractBackground While subthalamic nucleus deep brain stimulation (STN-DBS) improves the quality of life (QoL)of patients with Parkinson’s disease (PD), the clinical parameters that predict this improvement remain debated. Thisretrospective study explored whether preoperative motor, cognitive, and affective parameters predict QoL or its componentsat 6 and 12 months after STN-DBS surgery.Methods QoL was assessed with the Parkinson’s Disease Questionnaire-39 (PDQ-39) before (baseline), at 6 months(N = 90) and 12 months (N = 63) after STN-DBS surgery. Changes in the PDQ-39 and its subdomains were analysedwith Wilcoxon signed-rank tests. In total, seven motor, cognitive, and affective parameters recorded at baseline wereused in multiple linear regressions to predict QoL and its subdomains.Results QoL had improved significantly at six months post STN-DBS surgery. After 12 months, this effect remainedsignificant but was less pronounced. At both time points, significant improvements in mobility, activities of daily living,stigma, and bodily discomfort were present. Correlation and linear regression analyses showed that preoperativeQoL status and changes in QoL at 6 and 12 months after surgery were driven by preoperative dopaminergic medication,as well as motor (UPDRS-III medOFF and PIGD-subscore medOFF) and affective (HADS anxiety and depression)symptoms. In contrast, preoperative cognitive performance did not predict QoL at any time point.Conclusion Data show that preoperative motor and affective symptoms drive both QoL baseline status and changesin QoL after STN-DBS surgery. Thus, these clinical parameters need to be assessed appropriately to provide comprehensivepresurgical advice to patients suffering from PD.
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001023519 7001_ $$0P:(DE-HGF)0$$aStopic, Vasilija$$b1
001023519 7001_ $$0P:(DE-HGF)0$$aJost, Stefanie T.$$b2
001023519 7001_ $$0P:(DE-Juel1)131720$$aFink, Gereon R.$$b3$$ufzj
001023519 7001_ $$0P:(DE-Juel1)131748$$aWeiss-Blankenhorn, Peter$$b4$$ufzj
001023519 7001_ $$0P:(DE-Juel1)131613$$aBarbe, Michael T.$$b5
001023519 773__ $$0PERI:(DE-600)2947493-0$$a10.1186/s42466-023-00303-2$$gVol. 6, no. 1, p. 8$$n1$$p8$$tNeurological research and practice$$v6$$x2524-3489$$y2024
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