% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@ARTICLE{Semmler:1023519,
      author       = {Semmler, Carolin and Stopic, Vasilija and Jost, Stefanie T.
                      and Fink, Gereon R. and Weiss-Blankenhorn, Peter and Barbe,
                      Michael T.},
      title        = {{P}reoperative motor deficits and depressive symptoms
                      predict quality of life in patients with {P}arkinson’s
                      disease at different time points after surgery for
                      subthalamic stimulation: a retrospective study},
      journal      = {Neurological research and practice},
      volume       = {6},
      number       = {1},
      issn         = {2524-3489},
      address      = {[London]},
      publisher    = {BioMed Central},
      reportid     = {FZJ-2024-01730},
      pages        = {8},
      year         = {2024},
      abstract     = {AbstractBackground While subthalamic nucleus deep brain
                      stimulation (STN-DBS) improves the quality of life (QoL)of
                      patients with Parkinson’s disease (PD), the clinical
                      parameters that predict this improvement remain debated.
                      Thisretrospective study explored whether preoperative motor,
                      cognitive, and affective parameters predict QoL or its
                      componentsat 6 and 12 months after STN-DBS surgery.Methods
                      QoL was assessed with the Parkinson’s Disease
                      Questionnaire-39 (PDQ-39) before (baseline), at 6 months(N =
                      90) and 12 months (N = 63) after STN-DBS surgery. Changes in
                      the PDQ-39 and its subdomains were analysedwith Wilcoxon
                      signed-rank tests. In total, seven motor, cognitive, and
                      affective parameters recorded at baseline wereused in
                      multiple linear regressions to predict QoL and its
                      subdomains.Results QoL had improved significantly at six
                      months post STN-DBS surgery. After 12 months, this effect
                      remainedsignificant but was less pronounced. At both time
                      points, significant improvements in mobility, activities of
                      daily living,stigma, and bodily discomfort were present.
                      Correlation and linear regression analyses showed that
                      preoperativeQoL status and changes in QoL at 6 and 12 months
                      after surgery were driven by preoperative dopaminergic
                      medication,as well as motor (UPDRS-III medOFF and
                      PIGD-subscore medOFF) and affective (HADS anxiety and
                      depression)symptoms. In contrast, preoperative cognitive
                      performance did not predict QoL at any time point.Conclusion
                      Data show that preoperative motor and affective symptoms
                      drive both QoL baseline status and changesin QoL after
                      STN-DBS surgery. Thus, these clinical parameters need to be
                      assessed appropriately to provide comprehensivepresurgical
                      advice to patients suffering from PD.},
      cin          = {INM-3},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-3-20090406},
      pnm          = {5251 - Multilevel Brain Organization and Variability
                      (POF4-525) / DFG project G:(GEPRIS)431549029 - SFB 1451:
                      Schlüsselmechanismen normaler und krankheitsbedingt
                      gestörter motorischer Kontrolle (431549029)},
      pid          = {G:(DE-HGF)POF4-5251 / G:(GEPRIS)431549029},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {38326916},
      UT           = {WOS:001158415400001},
      doi          = {10.1186/s42466-023-00303-2},
      url          = {https://juser.fz-juelich.de/record/1023519},
}