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@ARTICLE{Koob:1023816,
      author       = {Koob, Janusz L and Gorski, Maximilian and Krick, Sebastian
                      and Mustin, Maike and Fink, Gereon R. and Grefkes, Christian
                      and Rehme, Anne K.},
      title        = {{B}ehavioral and neuroanatomical correlates of facial
                      emotion processing in post-stroke depression},
      journal      = {NeuroImage: Clinical},
      volume       = {41},
      issn         = {2213-1582},
      address      = {[Amsterdam u.a.]},
      publisher    = {Elsevier},
      reportid     = {FZJ-2024-01821},
      pages        = {103586 -},
      year         = {2024},
      abstract     = {AbstractBackground: Emotion processing deficits are known
                      to accompany depressive symptoms and are often seen in
                      stroke patients. Little is known about the influence of
                      post-stroke depressive (PSD) symptoms and specific brain
                      lesions on altered emotion processing abilities and how
                      these phenomena develop over time. This potential
                      relationship may impact post-stroke rehabilitation of
                      neurological and psychosocial function. To address this
                      scientific gap, we investigated the relationship between PSD
                      symptoms and emotion processing abilities in a longitudinal
                      study design from the first days post-stroke into the early
                      chronic phase.Methods: Twenty-six ischemic stroke patients
                      performed an emotion processing task on videos with
                      emotional faces ('happy,' 'sad,' 'anger,' 'fear,' and
                      'neutral') at different intensity levels $(20\%,$ $40\%,$
                      $60\%,$ $80\%,$ $100\%).$ Recognition accuracies and
                      response times were measured, as well as scores of
                      depressive symptoms (Montgomery-Åsberg Depression Rating
                      Scale). Twenty-eight healthy participants matched in age and
                      sex were included as a control group. Whole-brain
                      support-vector regression lesion-symptom mapping (SVR-LSM)
                      analyses were performed to investigate whether specific
                      lesion locations were associated with the recognition
                      accuracy of specific emotion categories.Results: Stroke
                      patients performed worse in overall recognition accuracy
                      compared to controls, specifically in the recognition of
                      happy, sad, and fearful faces. Notably, more depressed
                      stroke patients showed an increased processing towards
                      specific negative emotions, as they responded significantly
                      faster to angry faces and recognized sad faces of low
                      intensities significantly more accurately. These effects
                      obtained for the first days after stroke partly persisted to
                      follow-up assessment several months later. SVR-LSM analyses
                      revealed that inferior and middle frontal regions (IFG/MFG)
                      and insula and putamen were associated with
                      emotion-recognition deficits in stroke. Specifically,
                      recognizing happy facial expressions was influenced by
                      lesions affecting the anterior insula, putamen, IFG, MFG,
                      orbitofrontal cortex, and rolandic operculum. Lesions in the
                      posterior insula, rolandic operculum, and MFG were also
                      related to reduced recognition accuracy of fearful facial
                      expressions, whereas recognition deficits of sad faces were
                      associated with frontal pole, IFG, and MFG
                      damage.Conclusion: PSD symptoms facilitate processing
                      negative emotional stimuli, specifically angry and sad
                      facial expressions. The recognition accuracy of different
                      emotional categories was linked to brain lesions in
                      emotion-related processing circuits, including insula, basal
                      ganglia, IFG, and MFG. In summary, our study provides
                      support for psychosocial and neural factors underlying
                      emotional processing after stroke, contributing to the
                      pathophysiology of PSD.Keywords: Dynamic faces; Emotion
                      processing; Longitudinal; Multivariate SVR-LSM; PSD.},
      cin          = {INM-3},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-3-20090406},
      pnm          = {5251 - Multilevel Brain Organization and Variability
                      (POF4-525) / DFG project 310098283 - Neurale Grundlagen der
                      Interaktion von Post-stroke Depression und motorischer
                      Rehabilitation nach Schlaganfall (310098283)},
      pid          = {G:(DE-HGF)POF4-5251 / G:(GEPRIS)310098283},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {38428325},
      UT           = {WOS:001218586600001},
      doi          = {10.1016/j.nicl.2024.103586},
      url          = {https://juser.fz-juelich.de/record/1023816},
}