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@ARTICLE{Dong:1024146,
      author       = {Dong, Debo and Chen, Ximei and Li, Wei and Gao, Xiao and
                      Wang, Yulin and Zhou, Feng and Eickhoff, Simon B. and Chen,
                      Hongzhu},
      title        = {{O}pposite changes in morphometric similarity of medial
                      reward and lateral non-reward orbitofrontal cortex circuits
                      in obesity},
      journal      = {NeuroImage},
      volume       = {290},
      issn         = {1053-8119},
      address      = {Orlando, Fla.},
      publisher    = {Academic Press},
      reportid     = {FZJ-2024-01988},
      pages        = {120574 -},
      year         = {2024},
      abstract     = {Obesity has a profound impact on metabolic health thereby
                      adversely affecting brain structure and function. However,
                      the majority of previous studies used a single structural
                      index to investigate the link between brain structure and
                      body mass index (BMI), which hinders our understanding of
                      structural covariance between regions in obesity. This study
                      aimed to examine the relationship between macroscale
                      cortical organization and BMI using novel morphometric
                      similarity networks (MSNs). The individual MSNs were first
                      constructed from individual eight multimodal cortical
                      morphometric features between brain regions. Then the
                      relationship between BMI and MSNs within the discovery
                      sample of 434 participants was assessed. The key findings
                      were further validated in an independent sample of 192
                      participants. We observed that the lateral non-reward
                      orbitofrontal cortex (lOFC) exhibited decoupling (i.e.,
                      reduction in integration) in obesity, which was mainly
                      manifested by its decoupling with the cognitive systems
                      (i.e., DMN and FPN) while the medial reward orbitofrontal
                      cortex (mOFC) showed de-differentiation (i.e., decrease in
                      distinctiveness) in obesity, which was mainly represented by
                      its de-differentiation with the cognitive and attention
                      systems (i.e., DMN and VAN). Additionally, the lOFC showed
                      de-differentiation with the visual system in obesity, while
                      the mOFC showed decoupling with the visual system and
                      hyper-coupling with the sensory-motor system in obesity. As
                      an important first step in revealing the role of underlying
                      structural covariance in body mass variability, the present
                      study presents a novel mechanism that underlies the
                      reward-control interaction imbalance in obesity, thus can
                      inform future weight-management approaches.},
      cin          = {INM-7},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-7-20090406},
      pnm          = {5251 - Multilevel Brain Organization and Variability
                      (POF4-525) / 5252 - Brain Dysfunction and Plasticity
                      (POF4-525)},
      pid          = {G:(DE-HGF)POF4-5251 / G:(DE-HGF)POF4-5252},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {38467346},
      UT           = {WOS:001211284200001},
      doi          = {10.1016/j.neuroimage.2024.120574},
      url          = {https://juser.fz-juelich.de/record/1024146},
}