001     1024402
005     20250204113820.0
024 7 _ |a 10.1016/j.compbiomed.2024.108383
|2 doi
024 7 _ |a 0010-4825
|2 ISSN
024 7 _ |a 1879-0534
|2 ISSN
024 7 _ |a 10.34734/FZJ-2024-02145
|2 datacite_doi
037 _ _ |a FZJ-2024-02145
041 _ _ |a English
082 _ _ |a 570
100 1 _ |a Rüttgers, Mario
|0 P:(DE-Juel1)177985
|b 0
|e Corresponding author
245 _ _ |a Automated surgery planning for an obstructed nose by combining computational fluid dynamics with reinforcement learning
260 _ _ |a Amsterdam [u.a.]
|c 2024
|b Elsevier Science
336 7 _ |a article
|2 DRIVER
336 7 _ |a Output Types/Journal article
|2 DataCite
336 7 _ |a Journal Article
|b journal
|m journal
|0 PUB:(DE-HGF)16
|s 1712139634_23612
|2 PUB:(DE-HGF)
336 7 _ |a ARTICLE
|2 BibTeX
336 7 _ |a JOURNAL_ARTICLE
|2 ORCID
336 7 _ |a Journal Article
|0 0
|2 EndNote
520 _ _ |a Septoplasty and turbinectomy are among the most common interventions in the field of rhinology. Their constantly debated success rates and the lack of quantitative flow data of the entire nasal airway for planning the surgery necessitate methodological improvement. Thus, physics-based surgery planning is highly desirable. In this work, a novel and accurate method is developed to enhance surgery planning by physical aspects of respiration, i.e., to plan anti-obstructive surgery, for the first time a reinforcement learning algorithm is combined with large-scale computational fluid dynamics simulations. The method is integrated into an automated pipeline based on computed tomography imaging. The proposed surgical intervention is compared to a surgeon’s initial plan, or the maximum possible intervention, which allows the quantitative evaluation of the intended surgery. Two criteria are considered: (i) the capability to supply the nasal airway with air expressed by the pressure loss and (ii) the capability to heat incoming air represented by the temperature increase. For a test patient suffering from a deviated septum near the nostrils and a bony spur further downstream, the method recommends surgical interventions exactly at these locations. For equal weights on the two criteria (i) and (ii), the algorithm proposes a slightly weaker correction of the deviated septum at the first location, compared to the surgeon’s plan. At the second location, the algorithm proposes to keep the bony spur. For a larger weight on criterion (i), the algorithm tends to widen the nasal passage by removing the bony spur. For a larger weight on criterion (ii), the algorithm’s suggestion approaches the pre-surgical state with narrowed channels that favor heat transfer. A second patient is investigated that suffers from enlarged turbinates in the left nasal passage. For equal weights on the two criteria (i) and (ii), the algorithm proposes a nearly complete removal of the inferior turbinate, and a moderate reduction of the middle turbinate. An increased weight on criterion (i) leads to an additional reduction of the middle turbinate, and a larger weight on criterion (ii) yields a solution with only slight reductions of both turbinates, i.e., focusing on a sufficient heat exchange between incoming air and the air-nose interface. The proposed method has the potential to improve the success rates of the aforementioned surgeries and can be extended to further biomedical flows.
536 _ _ |a 5111 - Domain-Specific Simulation & Data Life Cycle Labs (SDLs) and Research Groups (POF4-511)
|0 G:(DE-HGF)POF4-5111
|c POF4-511
|f POF IV
|x 0
536 _ _ |a RAISE - Research on AI- and Simulation-Based Engineering at Exascale (951733)
|0 G:(EU-Grant)951733
|c 951733
|f H2020-INFRAEDI-2019-1
|x 1
536 _ _ |a HDS LEE - Helmholtz School for Data Science in Life, Earth and Energy (HDS LEE) (HDS-LEE-20190612)
|0 G:(DE-Juel1)HDS-LEE-20190612
|c HDS-LEE-20190612
|x 2
588 _ _ |a Dataset connected to CrossRef, Journals: juser.fz-juelich.de
700 1 _ |a Waldmann, Moritz
|0 P:(DE-HGF)0
|b 1
700 1 _ |a Vogt, Klaus
|0 0000-0002-9926-5273
|b 2
700 1 _ |a Ilgner, Justus
|0 P:(DE-HGF)0
|b 3
700 1 _ |a Schröder, Wolfgang
|0 0000-0002-3472-1813
|b 4
700 1 _ |a Lintermann, Andreas
|0 P:(DE-Juel1)165948
|b 5
|u fzj
773 _ _ |a 10.1016/j.compbiomed.2024.108383
|g Vol. 173, p. 108383 -
|0 PERI:(DE-600)1496984-1
|p 108383
|t Computers in biology and medicine
|v 173
|y 2024
|x 0010-4825
856 4 _ |y OpenAccess
|u https://juser.fz-juelich.de/record/1024402/files/1-s2.0-S0010482524004670-main.pdf
856 4 _ |y OpenAccess
|x icon
|u https://juser.fz-juelich.de/record/1024402/files/1-s2.0-S0010482524004670-main.gif?subformat=icon
856 4 _ |y OpenAccess
|x icon-1440
|u https://juser.fz-juelich.de/record/1024402/files/1-s2.0-S0010482524004670-main.jpg?subformat=icon-1440
856 4 _ |y OpenAccess
|x icon-180
|u https://juser.fz-juelich.de/record/1024402/files/1-s2.0-S0010482524004670-main.jpg?subformat=icon-180
856 4 _ |y OpenAccess
|x icon-640
|u https://juser.fz-juelich.de/record/1024402/files/1-s2.0-S0010482524004670-main.jpg?subformat=icon-640
909 C O |o oai:juser.fz-juelich.de:1024402
|p openaire
|p open_access
|p OpenAPC_DEAL
|p driver
|p VDB
|p ec_fundedresources
|p openCost
|p dnbdelivery
910 1 _ |a Forschungszentrum Jülich
|0 I:(DE-588b)5008462-8
|k FZJ
|b 0
|6 P:(DE-Juel1)177985
910 1 _ |a RWTH Aachen
|0 I:(DE-588b)36225-6
|k RWTH
|b 1
|6 P:(DE-HGF)0
910 1 _ |a RWTH Aachen
|0 I:(DE-588b)36225-6
|k RWTH
|b 4
|6 0000-0002-3472-1813
910 1 _ |a Forschungszentrum Jülich
|0 I:(DE-588b)5008462-8
|k FZJ
|b 5
|6 P:(DE-Juel1)165948
913 1 _ |a DE-HGF
|b Key Technologies
|l Engineering Digital Futures – Supercomputing, Data Management and Information Security for Knowledge and Action
|1 G:(DE-HGF)POF4-510
|0 G:(DE-HGF)POF4-511
|3 G:(DE-HGF)POF4
|2 G:(DE-HGF)POF4-500
|4 G:(DE-HGF)POF
|v Enabling Computational- & Data-Intensive Science and Engineering
|9 G:(DE-HGF)POF4-5111
|x 0
914 1 _ |y 2024
915 p c |a APC keys set
|2 APC
|0 PC:(DE-HGF)0000
915 p c |a Local Funding
|2 APC
|0 PC:(DE-HGF)0001
915 p c |a DFG OA Publikationskosten
|2 APC
|0 PC:(DE-HGF)0002
915 p c |a DEAL: Elsevier 09/01/2023
|2 APC
|0 PC:(DE-HGF)0125
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0160
|2 StatID
|b Essential Science Indicators
|d 2023-08-25
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)1190
|2 StatID
|b Biological Abstracts
|d 2023-08-25
915 _ _ |a Creative Commons Attribution-NonCommercial CC BY-NC 4.0
|0 LIC:(DE-HGF)CCBYNC4
|2 HGFVOC
915 _ _ |a WoS
|0 StatID:(DE-HGF)0113
|2 StatID
|b Science Citation Index Expanded
|d 2023-08-25
915 _ _ |a OpenAccess
|0 StatID:(DE-HGF)0510
|2 StatID
915 _ _ |a Nationallizenz
|0 StatID:(DE-HGF)0420
|2 StatID
|d 2024-12-18
|w ger
915 _ _ |a JCR
|0 StatID:(DE-HGF)0100
|2 StatID
|b COMPUT BIOL MED : 2022
|d 2024-12-18
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0200
|2 StatID
|b SCOPUS
|d 2024-12-18
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0300
|2 StatID
|b Medline
|d 2024-12-18
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0600
|2 StatID
|b Ebsco Academic Search
|d 2024-12-18
915 _ _ |a Peer Review
|0 StatID:(DE-HGF)0030
|2 StatID
|b ASC
|d 2024-12-18
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0199
|2 StatID
|b Clarivate Analytics Master Journal List
|d 2024-12-18
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)1050
|2 StatID
|b BIOSIS Previews
|d 2024-12-18
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)1030
|2 StatID
|b Current Contents - Life Sciences
|d 2024-12-18
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0150
|2 StatID
|b Web of Science Core Collection
|d 2024-12-18
915 _ _ |a IF >= 5
|0 StatID:(DE-HGF)9905
|2 StatID
|b COMPUT BIOL MED : 2022
|d 2024-12-18
920 _ _ |l yes
920 1 _ |0 I:(DE-Juel1)JSC-20090406
|k JSC
|l Jülich Supercomputing Center
|x 0
980 1 _ |a FullTexts
980 _ _ |a journal
980 _ _ |a VDB
980 _ _ |a UNRESTRICTED
980 _ _ |a I:(DE-Juel1)JSC-20090406
980 _ _ |a APC


LibraryCollectionCLSMajorCLSMinorLanguageAuthor
Marc 21