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001024599 1001_ $$0P:(DE-HGF)0$$aDoering, Elena$$b0$$eCorresponding author
001024599 245__ $$aA Volume‐Based Alternative for classifying ATN: Data from the Tau Propagation over Time (T‐POT) cohort
001024599 260__ $$aHoboken, NJ$$bWiley$$c2023
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001024599 520__ $$aBackground:Alzheimer’sdisease(AD)ischaracterizedbythecerebralaccumulationofamyloid-beta(A),tau(T),andprogressiveneurodegeneration(N).ThewidelyusedATNsystem,withregardtopositronemissiontomography(PET)biomarkers,catego-rizesADbasedonthemeansignalinspecificregionsofinterest(ROI).However,thisprocedure disregards the spatial extent of pathology and neurodegeneration. Here,weproposeanalternativequantificationofthevolume,i.e.,fillstates,ofA,TandNin(pre)-clinicalAD.Method:WeanalyzeddatafromtheTauPropagationoverTime(T-POT)study,includ-ingcognitivelyunimpairedindividuals(CU,n=58),andpatientswithmildcognitiveimpairment(MCI,n=20)orADdementia(n=4).C11-PIB-PET(A),18F-AV1451(T)andperfusion-phase18F-AV1451scans(N)werespatiallyandintensity-normalized(reference:cerebellum).ToquantifythevolumeofA,TandN,wez-standardizedandsubsequentlybinarizedallscanswithin–modalityusingaz-scorethreshold.Fillstateswerethencomputedasthesumofabnormalvoxelsrelativetoawhole-brainmask.Finally,meanfillstateswerecomparedacrossgroupsofclinicalstatus(CU,MCI,AD)andpartialcorrelationsofeitherfillstatesormeanPETsignalinestablished,tracer-specificROIswithcognitiveperformance(MMSE)werecomputed,adjustingforage,sexandeducation.Result:Meanfillstatesreflectedclinicalstatus,astheyincreasedwithdiseaseprogres-sion(CU:A=4%,T=4%,N=3%;MCI:A=15%,T=11%,N=4%;ADdementia:A=20%,T=23%,N=5%).Moreover,AandTfillstateswerenegativelyassociatedwithMMSE(rhoA=-.299,p<.001;rhoT=-.318,p<.01;rhoN=-.147,p=.20),whileassoci-Alzheimer’sDement.2023;19(Suppl.24):e082991.©2023theAlzheimer’sAssociation.1of2wileyonlinelibrary.com/journal/alzhttps://doi.org/10.1002/alz.0829912of2BIOMARKERSationsofmeanPETsignalandMMSEtendedtobeweaker(rhoA(global)=-.255,p=.03;rhoT(temporalmetaROI)=-.275,p=.01;rhoN(metaROI)=.179,p=.12).Conclusion:We present a competitive quantification scheme for ATN that is asso-ciated with both, clinical status and cognitive performance. These results, whilecurrently validated in a larger sample, suggest that the spatiotemporal dynamics ofpathologyandneurodegenerationintheADcontinuumarewellcapturedbyourmulti-parametricapproach,whichispossiblysuperiorcomparedtoclassificationfrommeanPETsignalintensity.
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001024599 7001_ $$0P:(DE-Juel1)178642$$aHönig, Merle C.$$b1$$ufzj
001024599 7001_ $$0P:(DE-HGF)0$$aDzialas, Verena$$b2
001024599 7001_ $$0P:(DE-HGF)0$$aLothmann, Julia$$b3
001024599 7001_ $$0P:(DE-Juel1)178805$$aGiehl, Kathrin$$b4$$ufzj
001024599 7001_ $$0P:(DE-HGF)0$$aTheis, Hendrik$$b5
001024599 7001_ $$0P:(DE-HGF)0$$aJäger, Elena$$b6
001024599 7001_ $$0P:(DE-HGF)0$$aAndrassy, Gregory$$b7
001024599 7001_ $$0P:(DE-Juel1)131672$$aBauer, Andreas$$b8$$ufzj
001024599 7001_ $$0P:(DE-Juel1)131679$$aElmenhorst, David$$b9$$ufzj
001024599 7001_ $$0P:(DE-Juel1)131691$$aKroll, Tina$$b10$$ufzj
001024599 7001_ $$0P:(DE-Juel1)138474$$aMatusch, Andreas$$b11$$ufzj
001024599 7001_ $$0P:(DE-Juel1)169356$$aKrapf, Philip$$b12$$ufzj
001024599 7001_ $$0P:(DE-Juel1)166419$$aNeumaier, Bernd$$b13$$ufzj
001024599 7001_ $$0P:(DE-Juel1)164254$$aLerche, Christoph$$b14$$ufzj
001024599 7001_ $$0P:(DE-Juel1)131797$$aTellmann, Lutz$$b15$$ufzj
001024599 7001_ $$0P:(DE-Juel1)162267$$aFrensch, Silke$$b16$$ufzj
001024599 7001_ $$0P:(DE-HGF)0$$aZeyen, Philip$$b17
001024599 7001_ $$0P:(DE-HGF)0$$aSand, Frederik$$b18
001024599 7001_ $$0P:(DE-Juel1)167565$$aRichter, Nils$$b19$$ufzj
001024599 7001_ $$0P:(DE-HGF)0$$aJessen, Frank$$b20
001024599 7001_ $$0P:(DE-HGF)0$$aOnur, Oezguer A.$$b21
001024599 7001_ $$0P:(DE-HGF)0$$aRamirez, Alfredo$$b22
001024599 7001_ $$0P:(DE-Juel1)169110$$avan Eimeren, Thilo$$b23
001024599 7001_ $$0P:(DE-Juel1)177611$$aDrzezga, Alexander$$b24$$ufzj
001024599 7001_ $$0P:(DE-Juel1)166265$$aBischof, Gerard N$$b25$$ufzj
001024599 773__ $$0PERI:(DE-600)2201940-6$$a10.1002/alz.082991$$gVol. 19, no. S24, p. e082991$$nS24$$pe082991$$tAlzheimer's and dementia$$v19$$x1552-5260$$y2023
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