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@ARTICLE{Valk:1024837,
      author       = {Valk, Sofie Louise and Kanske, Philipp and Park, Bo-yong
                      and Hong, Seok-Jun and Böckler, Anne and Trautwein,
                      Fynn-Mathis and Bernhardt, Boris C and Singer, Tania},
      title        = {{F}unctional and microstructural plasticity following
                      social and interoceptive mental training},
      journal      = {eLife},
      volume       = {12},
      issn         = {2050-084X},
      address      = {Cambridge},
      publisher    = {eLife Sciences Publications},
      reportid     = {FZJ-2024-02503},
      pages        = {e85188},
      year         = {2023},
      abstract     = {The human brain supports social cognitive functions,
                      including Theory of Mind, empathy, and compassion, through
                      its intrinsic hierarchical organization. However, it remains
                      unclear how the learning and refinement of social skills
                      shapes brain function and structure. We studied if different
                      types of social mental training induce changes in cortical
                      function and microstructure, investigating 332 healthy
                      adults (197 women, 20–55 years) with repeated multimodal
                      neuroimaging and behavioral testing. Our neuroimaging
                      approach examined longitudinal changes in cortical
                      functional gradients and myelin-sensitive T1 relaxometry,
                      two complementary measures of cortical hierarchical
                      organization. We observed marked changes in intrinsic
                      cortical function and microstructure, which varied as a
                      function of social training content. In particular, cortical
                      function and microstructure changed as a result of
                      attention-mindfulness and socio-cognitive training in
                      regions functionally associated with attention and
                      interoception, including insular and parietal cortices.
                      Conversely, socio-affective and socio-cognitive training
                      resulted in differential microstructural changes in regions
                      classically implicated in interoceptive and emotional
                      processing, including insular and orbitofrontal areas, but
                      did not result in functional reorganization. Notably,
                      longitudinal changes in cortical function and microstructure
                      predicted behavioral change in attention, compassion and
                      perspective-taking. Our work demonstrates functional and
                      microstructural plasticity after the training of
                      social-interoceptive functions, and illustrates the
                      bidirectional relationship between brain organisation and
                      human social skills.},
      cin          = {INM-7},
      ddc          = {600},
      cid          = {I:(DE-Juel1)INM-7-20090406},
      pnm          = {5252 - Brain Dysfunction and Plasticity (POF4-525)},
      pid          = {G:(DE-HGF)POF4-5252},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {37417306},
      UT           = {WOS:001046785200001},
      doi          = {10.7554/eLife.85188},
      url          = {https://juser.fz-juelich.de/record/1024837},
}