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@ARTICLE{Morys:1024839,
      author       = {Morys, Filip and Yu, Eric and Shishikura, Mari and Paquola,
                      Casey and Vainik, Uku and Nave, Gideon and Koellinger,
                      Philipp and Gan-Or, Ziv and Dagher, Alain},
      title        = {{N}euroanatomical correlates of genetic risk for obesity in
                      children},
      journal      = {Translational Psychiatry},
      volume       = {13},
      number       = {1},
      issn         = {2158-3188},
      address      = {London},
      publisher    = {Nature Publishing Group},
      reportid     = {FZJ-2024-02505},
      pages        = {1},
      year         = {2023},
      abstract     = {Obesity has a strong genetic component, with up to $20\%$
                      of variance in body mass index (BMI) being accounted for by
                      common polygenic variation. Most genetic polymorphisms
                      associated with BMI are related to genes expressed in the
                      central nervous system. At the same time, higher BMI is
                      associated with neurocognitive changes. However, the direct
                      link between genetics of obesity and neurobehavioral
                      mechanisms related to weight gain is missing. Here, we use a
                      large sample of participants (n > 4000) from the
                      Adolescent Brain Cognitive Development cohort to investigate
                      how genetic risk for obesity, expressed as polygenic risk
                      score for BMI (BMI-PRS), is related to brain and behavioral
                      measures in adolescents. In a series of analyses, we show
                      that BMI-PRS is related to lower cortical volume and
                      thickness in the frontal and temporal areas, relative to
                      age-expected values. Relatedly, using structural equation
                      modeling, we find that lower overall cortical volume is
                      associated with higher impulsivity, which in turn is related
                      to an increase in BMI 1 year later. In sum, our study shows
                      that obesity might partially stem from genetic risk as
                      expressed in brain changes in the frontal and temporal brain
                      areas, and changes in impulsivity.},
      cin          = {INM-7},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-7-20090406},
      pnm          = {5253 - Neuroimaging (POF4-525) / 5251 - Multilevel Brain
                      Organization and Variability (POF4-525)},
      pid          = {G:(DE-HGF)POF4-5253 / G:(DE-HGF)POF4-5251},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {36596778},
      UT           = {WOS:000907127600001},
      doi          = {10.1038/s41398-022-02301-5},
      url          = {https://juser.fz-juelich.de/record/1024839},
}