% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@ARTICLE{Royer:1024848,
      author       = {Royer, Jessica and Larivière, Sara and Rodriguez-Cruces,
                      Raul and Cabalo, Donna Gift and Tavakol, Shahin and Auer,
                      Hans and Ngo, Alexander and Park, Bo-yong and Paquola, Casey
                      and Smallwood, Jonathan and Jefferies, Elizabeth and
                      Caciagli, Lorenzo and Bernasconi, Andrea and Bernasconi,
                      Neda and Frauscher, Birgit and Bernhardt, Boris C},
      title        = {{C}ortical microstructural gradients capture memory network
                      reorganization in temporal lobe epilepsy},
      journal      = {Brain},
      volume       = {146},
      number       = {9},
      issn         = {0006-8950},
      address      = {Oxford},
      publisher    = {Oxford Univ. Press},
      reportid     = {FZJ-2024-02514},
      pages        = {3923 - 3937},
      year         = {2023},
      abstract     = {Temporal lobe epilepsy (TLE), one of the most common
                      pharmaco-resistant epilepsies, is associated with pathology
                      of paralimbic brain regions, particularly in the
                      mesiotemporal lobe. Cognitive dysfunction in TLE is
                      frequent, and particularly affects episodic memory.
                      Crucially, these difficulties challenge the quality of life
                      of patients, sometimes more than seizures, underscoring the
                      need to assess neural processes of cognitive dysfunction in
                      TLE to improve patient management.Our work harnessed a novel
                      conceptual and analytical approach to assess spatial
                      gradients of microstructural differentiation between
                      cortical areas based on high-resolution MRI analysis.
                      Gradients track region-to-region variations in intracortical
                      lamination and myeloarchitecture, serving as a system-level
                      measure of structural and functional
                      reorganization.Comparing cortex-wide microstructural
                      gradients between 21 patients and 35 healthy controls, we
                      observed a reorganization of this gradient in TLE driven by
                      reduced microstructural differentiation between paralimbic
                      cortices and the remaining cortex with marked abnormalities
                      in ipsilateral temporopolar and dorsolateral prefrontal
                      regions. Findings were replicated in an independent cohort.
                      Using an independent post-mortem dataset, we observed that
                      in vivo findings reflected topographical variations in
                      cortical cytoarchitecture. We indeed found that macroscale
                      changes in microstructural differentiation in TLE reflected
                      increased similarity of paralimbic and primary sensory/motor
                      regions. Disease-related transcriptomics could furthermore
                      show specificity of our findings to TLE over other common
                      epilepsy syndromes. Finally, microstructural
                      dedifferentiation was associated with cognitive network
                      reorganization seen during an episodic memory functional MRI
                      paradigm and correlated with interindividual differences in
                      task accuracy.Collectively, our findings showing a pattern
                      of reduced microarchitectural differentiation between
                      paralimbic regions and the remaining cortex provide a
                      structurally-grounded explanation for large-scale functional
                      network reorganization and cognitive dysfunction
                      characteristic of TLE.},
      cin          = {INM-7},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-7-20090406},
      pnm          = {5251 - Multilevel Brain Organization and Variability
                      (POF4-525) / 5253 - Neuroimaging (POF4-525)},
      pid          = {G:(DE-HGF)POF4-5251 / G:(DE-HGF)POF4-5253},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {37082950},
      UT           = {WOS:001002766100001},
      doi          = {10.1093/brain/awad125},
      url          = {https://juser.fz-juelich.de/record/1024848},
}