001024887 001__ 1024887 001024887 005__ 20250204113832.0 001024887 0247_ $$2doi$$a10.1016/j.clinph.2023.12.074 001024887 0247_ $$2ISSN$$a1388-2457 001024887 0247_ $$2ISSN$$a0921-884X 001024887 0247_ $$2ISSN$$a1872-8952 001024887 037__ $$aFZJ-2024-02538 001024887 082__ $$a610 001024887 1001_ $$0P:(DE-Juel1)188387$$aFedermann, L.$$b0$$eCorresponding author 001024887 1112_ $$aCongress for Clinical Neuroscience with Advanced Training Academy (DGKN24) of the German Society for Clinical Neurophysiology and Functional Neuroimaging (DGKN)$$cFrankfurt am Main$$d2024-03-06 - 2024-03-09$$wGermany 001024887 245__ $$aLinking brain structure and genetic risk in large-scale data: A comparison of shared versus predominantly disorder-specific genetic risk for neuropsychiatric disorders 001024887 260__ $$aAmsterdam [u.a.]$$bElsevier Science$$c2024 001024887 300__ $$a29-30 001024887 3367_ $$2ORCID$$aCONFERENCE_PAPER 001024887 3367_ $$033$$2EndNote$$aConference Paper 001024887 3367_ $$2BibTeX$$aINPROCEEDINGS 001024887 3367_ $$2DRIVER$$aconferenceObject 001024887 3367_ $$2DataCite$$aOutput Types/Conference Paper 001024887 3367_ $$0PUB:(DE-HGF)8$$2PUB:(DE-HGF)$$aContribution to a conference proceedings$$bcontrib$$mcontrib$$s1714571269_3375 001024887 520__ $$aShared and predominantly disorder-specific common genetic risk variants for neuropsychiatric disorders have been identified in previous studies. In particular, a large-scale genome-wide association study meta-analysis across eight neuropsychiatric disorders reported 23 highly pleiotropic single-nucleotide polymorphisms (SNPs) that are associated with at least four disorders as well as 22 SNPs that were predominantly associated with schizophrenia (SCZ) risk. Yet, their influences on brain structure which might be relevant for the increased vulnerability to multiple or specific neuropsychiatric disorders is not fully understood. In this study, we investigated and compared the cumulative influences of highly pleiotropic and predominantly SCZ-specific SNPs at the level of brain structure in the general population. Comparing their brain structural associations might point to brain regions of high transdiagnostic value as well as brain regions relevant to SCZ-specific risk pathways. 001024887 536__ $$0G:(DE-HGF)POF4-5251$$a5251 - Multilevel Brain Organization and Variability (POF4-525)$$cPOF4-525$$fPOF IV$$x0 001024887 536__ $$0G:(DE-HGF)POF4-5252$$a5252 - Brain Dysfunction and Plasticity (POF4-525)$$cPOF4-525$$fPOF IV$$x1 001024887 588__ $$aDataset connected to CrossRef, Journals: juser.fz-juelich.de 001024887 7001_ $$0P:(DE-HGF)0$$aSindermann, L.$$b1 001024887 7001_ $$0P:(DE-HGF)0$$aPrimus, S.$$b2 001024887 7001_ $$0P:(DE-Juel1)185083$$aRaimondo, F.$$b3 001024887 7001_ $$0P:(DE-HGF)0$$aOexle, K.$$b4 001024887 7001_ $$0P:(DE-HGF)0$$aGoltermann, J.$$b5 001024887 7001_ $$0P:(DE-HGF)0$$aWinkelmann, J.$$b6 001024887 7001_ $$0P:(DE-HGF)0$$aNöthen, M. M.$$b7 001024887 7001_ $$0P:(DE-Juel1)131631$$aAmunts, K.$$b8 001024887 7001_ $$0P:(DE-Juel1)156419$$aMühleisen, T. 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