TY  - CONF
AU  - Federmann, L.
AU  - Sindermann, L.
AU  - Primus, S.
AU  - Raimondo, F.
AU  - Oexle, K.
AU  - Goltermann, J.
AU  - Winkelmann, J.
AU  - Nöthen, M. M.
AU  - Amunts, K.
AU  - Mühleisen, T. W.
AU  - Cichon, S.
AU  - Eickhoff, S. B.
AU  - Hoffstaedter, F.
AU  - Dannlowski, U.
AU  - Patil, K. R.
AU  - Forstner, A. J.
TI  - Linking brain structure and genetic risk in large-scale data: A comparison of shared versus predominantly disorder-specific genetic risk for neuropsychiatric disorders
VL  - 159
SN  - 1388-2457
CY  - Amsterdam [u.a.]
PB  - Elsevier Science
M1  - FZJ-2024-02538
SP  - e29 - e30
PY  - 2024
AB  - Shared and predominantly disorder-specific common genetic risk variants for neuropsychiatric disorders have been identified in previous studies. In particular, a large-scale genome-wide association study meta-analysis across eight neuropsychiatric disorders reported 23 highly pleiotropic single-nucleotide polymorphisms (SNPs) that are associated with at least four disorders as well as 22 SNPs that were predominantly associated with schizophrenia (SCZ) risk. Yet, their influences on brain structure which might be relevant for the increased vulnerability to multiple or specific neuropsychiatric disorders is not fully understood. In this study, we investigated and compared the cumulative influences of highly pleiotropic and predominantly SCZ-specific SNPs at the level of brain structure in the general population. Comparing their brain structural associations might point to brain regions of high transdiagnostic value as well as brain regions relevant to SCZ-specific risk pathways.
T2  - Congress for Clinical Neuroscience with Advanced Training Academy (DGKN24) of the German Society for Clinical Neurophysiology and Functional Neuroimaging (DGKN)
CY  - 6 Mar 2024 - 9 Mar 2024, Frankfurt am Main (Germany)
Y2  - 6 Mar 2024 - 9 Mar 2024
M2  - Frankfurt am Main, Germany
LB  - PUB:(DE-HGF)8
DO  - DOI:10.1016/j.clinph.2023.12.074
UR  - https://juser.fz-juelich.de/record/1024887
ER  -