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@INPROCEEDINGS{Kocher:1025208,
      author       = {Kocher, M. and Heinzel, A. and Mottaghy, F. M. and Filss,
                      C. and Stoffels, G. and Lohmann, P. and Friedrich, M. and
                      Shah, N. J. and Caspers, S. and Weiss Lucas, C. and Ruge, M.
                      I. and Galldiks, N. and Fink, G. R. and Langen, K.},
      title        = {{P}01.01.{A} {THE} {IMPACT} {OF} {BRAIN} {LESIONS} {ON}
                      {HEALTH}-{RELATED} {QUALITY} {OF} {LIFE} {IN} {PATIENTS}
                      {WITH} {WHO} {CNS} {GRADE} 3 {OR} 4 {GLIOMA}: {A}
                      {LESION}-{FUNCTION} {AND} {RESTING}-{STATE} {FMRI}
                      {ANALYSIS}},
      issn         = {1523-5866},
      reportid     = {FZJ-2024-02776},
      year         = {2023},
      abstract     = {BACKGROUNDIn glioma patients, tumor development and
                      multimodality therapy are associated with changes in
                      health-related quality of life (HRQoL). It is largely
                      unknown how different types and locations of tumor- and
                      treatment-related brain lesions, as well as their
                      relationship to white matter tracts and functional brain
                      networks, affect HRQoL.MATERIAL AND METHODSIn 121 patients
                      with pretreated gliomas of WHO CNS grades 3 or 4, structural
                      MRI, O-(2-[18F]fluoroethyl)-L-tyrosine (FET) PET,
                      resting-state functional MRI (rs-fMRI) and self-reported
                      HRQoL questionnaires (EORTC QLQ-C30/BN20) were obtained.
                      Resection cavities, T1-enhancing lesions, T2/FLAIR
                      hyperintensities, and lesions with pathologically increased
                      FET uptake were delineated. Effects of tumor lateralization,
                      involvement of white matter tracts or resting-state network
                      nodes by different types of lesions and within-network
                      rs-fMRI connectivity were analyzed in terms of their
                      interaction with HRQoL scores.RESULTSRight hemisphere
                      gliomas were associated with significantly less favorable
                      outcomes in physical, role, emotional and social
                      functioning, compared with left-sided tumors. Most
                      functional HRQoL scores correlated significantly with
                      right-sided white-matter tracts involvement by T2/FLAIR
                      hyperintensities and with loss of within-network functional
                      connectivity of right-sided nodes. Tumors of the left
                      hemisphere caused significantly more communication
                      deficits.CONCLUSIONIn pretreated high-grade gliomas, right
                      hemisphere lesions are associated with reduced HRQoL scores
                      in most functional domains except communication ability,
                      compared to tumors of the left hemisphere. These
                      relationships are mainly observed for T2/FLAIR lesions
                      involving structural and functional networks in the right
                      hemisphere. The data suggest that sparing the right
                      hemisphere from treatment-related tissue damage may improve
                      HRQoL in glioma patients.},
      month         = {Sep},
      date          = {2023-09-21},
      organization  = {18th Meeting of the European
                       Association of Neuro-Oncology,
                       Rotterdam (Netherlands), 21 Sep 2023 -
                       24 Sep 2023},
      cin          = {INM-1 / INM-4 / INM-3},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-1-20090406 / I:(DE-Juel1)INM-4-20090406 /
                      I:(DE-Juel1)INM-3-20090406},
      pnm          = {5251 - Multilevel Brain Organization and Variability
                      (POF4-525)},
      pid          = {G:(DE-HGF)POF4-5251},
      typ          = {PUB:(DE-HGF)1},
      UT           = {WOS:001300535600076},
      doi          = {10.1093/neuonc/noad137.075},
      url          = {https://juser.fz-juelich.de/record/1025208},
}