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@ARTICLE{Kav:1025412,
      author       = {Kav, Batuhan and Weikl, Thomas R. and Schneck, Emanuel},
      title        = {{M}easuring pico-{N}ewton {F}orces with {L}ipid {A}nchors
                      as {F}orce {S}ensors in {M}olecular {D}ynamics
                      {S}imulations},
      journal      = {The journal of physical chemistry / B},
      volume       = {127},
      number       = {18},
      issn         = {1520-6106},
      address      = {Washington, DC},
      publisher    = {Americal Chemical Society},
      reportid     = {FZJ-2024-02871},
      pages        = {4081 - 4089},
      year         = {2023},
      abstract     = {Binding forces between biomolecules are ubiquitous in
                      nature but sometimes as weak as a few pico-Newtons (pN). In
                      many cases, the binding partners are attached to
                      biomembranes with the help of a lipid anchor. One important
                      example are glycolipids that promote membrane adhesion
                      through weak carbohydrate–carbohydrate binding between
                      adjacent membranes. Here, we use molecular dynamics (MD)
                      simulations to quantify the forces generated by bonds
                      involving membrane-anchored molecules. We introduce a method
                      in which the protrusion of the lipid anchors from the
                      membrane acts as the force sensor. Our results with two
                      different glycolipids reveal binding forces of up to 20 pN
                      and corroborate the recent notion that
                      carbohydrate–carbohydrate interactions are generic rather
                      than specific.},
      cin          = {IBI-7},
      ddc          = {530},
      cid          = {I:(DE-Juel1)IBI-7-20200312},
      pnm          = {5241 - Molecular Information Processing in Cellular Systems
                      (POF4-524)},
      pid          = {G:(DE-HGF)POF4-5241},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {37127845},
      UT           = {WOS:001004706500001},
      doi          = {10.1021/acs.jpcb.3c00063},
      url          = {https://juser.fz-juelich.de/record/1025412},
}