001025604 001__ 1025604
001025604 005__ 20250203103256.0
001025604 020__ $$a978-3-031-36389-4
001025604 020__ $$a978-3-031-36390-0 (electronic)
001025604 0247_ $$2doi$$a10.1007/978-3-031-36390-0_28
001025604 037__ $$aFZJ-2024-02998
001025604 1001_ $$0P:(DE-HGF)0$$aBarciszewski, Jan$$b0$$eEditor
001025604 245__ $$aRNA-Processing DNAzymes
001025604 260__ $$aCham$$bSpringer International Publishing$$c2023
001025604 29510 $$aRNA Structure and Function / Barciszewski, Jan (Editor) ; Cham : Springer International Publishing, 2023, Chapter 28 ; ISSN: 2197-9731=2197-9758 ; ISBN: 978-3-031-36389-4=978-3-031-36390-0 ; doi:10.1007/978-3-031-36390-0
001025604 300__ $$a629 - 643
001025604 3367_ $$2ORCID$$aBOOK_CHAPTER
001025604 3367_ $$07$$2EndNote$$aBook Section
001025604 3367_ $$2DRIVER$$abookPart
001025604 3367_ $$2BibTeX$$aINBOOK
001025604 3367_ $$2DataCite$$aOutput Types/Book chapter
001025604 3367_ $$0PUB:(DE-HGF)7$$2PUB:(DE-HGF)$$aContribution to a book$$bcontb$$mcontb$$s1714576374_354
001025604 4900_ $$aRNA Technologies$$v14
001025604 520__ $$aThe great potential of nucleic acids as therapeutics has been recognized for a while but has experienced a tremendous attention with the recent development of RNA vaccines. In contrast to protein-targeting strategies, nucleic acid-based approaches often have the advantage that the required target selectivity is not realized via matching a specific structure, but plainly via the primary sequence of the applied RNA or DNA construct. This sequence is then either directly processed or comprises an additional unit capable of processing a target molecule. The latter is true for a number of DNA sequences, called DNAzymes, that are capable of both binding and processing a target with a high selectivity. While the mRNA technology has the inherent strength of bringing something into the system, RNA-processing DNA catalysts such as RNA-cleaving DNAzymes have the inherent strength of taking something out of the system. Consequently, the DNAzyme technology has the potential to emerge as counterpart to the mRNA technology. However, and in line with the endeavors that were required for the success of the mRNA technology, specific improvements need to be realized to unravel the full potential of RNA-processing DNAzymes. This review provides an overview of recent findings and remaining limitations.
001025604 536__ $$0G:(DE-HGF)POF4-5241$$a5241 - Molecular Information Processing in Cellular Systems (POF4-524)$$cPOF4-524$$fPOF IV$$x0
001025604 588__ $$aDataset connected to CrossRef Book Series, Journals: juser.fz-juelich.de
001025604 7001_ $$0P:(DE-HGF)0$$aSpan, Ingrid$$b1$$eCorresponding author
001025604 7001_ $$0P:(DE-Juel1)156341$$aEtzkorn, Manuel$$b2$$eCorresponding author$$ufzj
001025604 773__ $$a10.1007/978-3-031-36390-0_28
001025604 909CO $$ooai:juser.fz-juelich.de:1025604$$pVDB
001025604 9101_ $$0I:(DE-588b)5008462-8$$6P:(DE-Juel1)156341$$aForschungszentrum Jülich$$b2$$kFZJ
001025604 9131_ $$0G:(DE-HGF)POF4-524$$1G:(DE-HGF)POF4-520$$2G:(DE-HGF)POF4-500$$3G:(DE-HGF)POF4$$4G:(DE-HGF)POF$$9G:(DE-HGF)POF4-5241$$aDE-HGF$$bKey Technologies$$lNatural, Artificial and Cognitive Information Processing$$vMolecular and Cellular Information Processing$$x0
001025604 9141_ $$y2024
001025604 920__ $$lyes
001025604 9201_ $$0I:(DE-Juel1)IBI-7-20200312$$kIBI-7$$lStrukturbiochemie$$x0
001025604 980__ $$acontb
001025604 980__ $$aVDB
001025604 980__ $$aI:(DE-Juel1)IBI-7-20200312
001025604 980__ $$aUNRESTRICTED