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@INBOOK{Barciszewski:1025604,
      author       = {Span, Ingrid and Etzkorn, Manuel},
      editor       = {Barciszewski, Jan},
      title        = {{RNA}-{P}rocessing {DNA}zymes},
      volume       = {14},
      address      = {Cham},
      publisher    = {Springer International Publishing},
      reportid     = {FZJ-2024-02998},
      isbn         = {978-3-031-36389-4},
      series       = {RNA Technologies},
      pages        = {629 - 643},
      year         = {2023},
      comment      = {RNA Structure and Function / Barciszewski, Jan (Editor) ;
                      Cham : Springer International Publishing, 2023, Chapter 28 ;
                      ISSN: 2197-9731=2197-9758 ; ISBN:
                      978-3-031-36389-4=978-3-031-36390-0 ;
                      doi:10.1007/978-3-031-36390-0},
      booktitle     = {RNA Structure and Function /
                       Barciszewski, Jan (Editor) ; Cham :
                       Springer International Publishing,
                       2023, Chapter 28 ; ISSN:
                       2197-9731=2197-9758 ; ISBN:
                       978-3-031-36389-4=978-3-031-36390-0 ;
                       doi:10.1007/978-3-031-36390-0},
      abstract     = {The great potential of nucleic acids as therapeutics has
                      been recognized for a while but has experienced a tremendous
                      attention with the recent development of RNA vaccines. In
                      contrast to protein-targeting strategies, nucleic acid-based
                      approaches often have the advantage that the required target
                      selectivity is not realized via matching a specific
                      structure, but plainly via the primary sequence of the
                      applied RNA or DNA construct. This sequence is then either
                      directly processed or comprises an additional unit capable
                      of processing a target molecule. The latter is true for a
                      number of DNA sequences, called DNAzymes, that are capable
                      of both binding and processing a target with a high
                      selectivity. While the mRNA technology has the inherent
                      strength of bringing something into the system,
                      RNA-processing DNA catalysts such as RNA-cleaving DNAzymes
                      have the inherent strength of taking something out of the
                      system. Consequently, the DNAzyme technology has the
                      potential to emerge as counterpart to the mRNA technology.
                      However, and in line with the endeavors that were required
                      for the success of the mRNA technology, specific
                      improvements need to be realized to unravel the full
                      potential of RNA-processing DNAzymes. This review provides
                      an overview of recent findings and remaining limitations.},
      cin          = {IBI-7},
      cid          = {I:(DE-Juel1)IBI-7-20200312},
      pnm          = {5241 - Molecular Information Processing in Cellular Systems
                      (POF4-524)},
      pid          = {G:(DE-HGF)POF4-5241},
      typ          = {PUB:(DE-HGF)7},
      doi          = {10.1007/978-3-031-36390-0_28},
      url          = {https://juser.fz-juelich.de/record/1025604},
}