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@ARTICLE{Peinado:1025605,
      author       = {Peinado, Rafaela dos S. and Martins, Lucas G. and Pacca,
                      Carolina C. and Saivish, Marielena V. and Borsatto, Kelly C.
                      and Nogueira, Maurício L. and Tasic, Ljubica and Arni,
                      Raghuvir K. and Eberle, Raphael J. and Coronado, Mônika A.},
      title        = {{HR}-{MAS} {NMR} {M}etabolomics {P}rofile of {V}ero {C}ells
                      under the {I}nfluence of {V}irus {I}nfection and ns{P}2
                      {I}nhibitor: {A} {C}hikungunya {C}ase {S}tudy},
      journal      = {International journal of molecular sciences},
      volume       = {25},
      number       = {3},
      issn         = {1422-0067},
      address      = {Basel},
      publisher    = {Molecular Diversity Preservation International},
      reportid     = {FZJ-2024-02999},
      pages        = {1414 -},
      year         = {2024},
      abstract     = {Abstract: The arbovirus Chikungunya (CHIKV) is transmitted
                      by Aedes mosquitoes in urban environments, and in humans, it
                      triggers debilitating symptoms involving long-term
                      complications, including arthritis and Guillain-Barré
                      syndrome. The development of antiviral therapies is
                      relevant, as no efficacious vaccine or drug has yet been
                      approved for clinical application. As a detailed map of
                      molecules underlying the viral infection can be obtained
                      from the metabolome, we validated the metabolic signatures
                      of Vero E6 cells prior to infection (CC), following CHIKV
                      infection (CV) and also upon the inclusion of the nsP2
                      protease inhibitor wedelolactone (CWV), a coumestan which
                      inhibits viral replication processes. The metabolome groups
                      evidenced significant changes in the levels of lactate,
                      myo-inositol, phosphocholine, glucose, betaine and a few
                      specific amino acids. This study forms a preliminary basis
                      for identifying metabolites through HR-MAS NMR (High
                      Resolution Magic Angle Spinning Nuclear Magnetic Ressonance
                      Spectroscopy) and proposing the affected metabolic pathways
                      of cells following viral infection and upon incorporation of
                      putative antiviral molecules.},
      cin          = {IBI-7},
      ddc          = {540},
      cid          = {I:(DE-Juel1)IBI-7-20200312},
      pnm          = {5241 - Molecular Information Processing in Cellular Systems
                      (POF4-524)},
      pid          = {G:(DE-HGF)POF4-5241},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {38338694},
      UT           = {WOS:001161120400001},
      doi          = {10.3390/ijms25031414},
      url          = {https://juser.fz-juelich.de/record/1025605},
}