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@ARTICLE{Frieg:1025606,
      author       = {Frieg, Benedikt and Han, Mookyoung and Giller, Karin and
                      Dienemann, Christian and Riedel, Dietmar and Becker, Stefan
                      and Andreas, Loren B. and Griesinger, Christian and
                      Schröder, Gunnar F.},
      title        = {{C}ryo-{EM} structures of lipidic fibrils of amyloid-β
                      (1-40)},
      journal      = {Nature Communications},
      volume       = {15},
      number       = {1},
      issn         = {2041-1723},
      address      = {[London]},
      publisher    = {Nature Publishing Group UK},
      reportid     = {FZJ-2024-03000},
      pages        = {1297},
      year         = {2024},
      abstract     = {Alzheimer’s disease (AD) is a progressive and incurable
                      neurodegenerative disease characterized by the extracellular
                      deposition of amyloid plaques. Investigation into the
                      composition of these plaques revealed a high amount of
                      amyloid-β (Aβ) fibrils and a high concentration of lipids,
                      suggesting that fibrillipid interactions may also be
                      relevant for the pathogenesis of AD. Therefore, we grew
                      Aβ40 fibrils in the presence of lipid vesicles and
                      determined their structure by cryo-electron microscopy
                      (cryo-EM) to high resolution. The fold of the major
                      polymorph is similar to the structure of brain-seeded
                      fibrils reported previously. The majority of the lipids are
                      bound to the fibrils, as we show by cryo-EM and NMR
                      spectroscopy. This apparent lipid extraction from vesicles
                      observed here in vitro provides structural insights into
                      potentially disease-relevant fibril-lipid interactions.},
      cin          = {IBI-7},
      ddc          = {500},
      cid          = {I:(DE-Juel1)IBI-7-20200312},
      pnm          = {5244 - Information Processing in Neuronal Networks
                      (POF4-524)},
      pid          = {G:(DE-HGF)POF4-5244},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {38351005},
      UT           = {WOS:001161933400016},
      doi          = {10.1038/s41467-023-43822-x},
      url          = {https://juser.fz-juelich.de/record/1025606},
}