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@ARTICLE{Sanyasi:1025609,
      author       = {Sanyasi, Chandrasekar and Balakrishnan, Susmida Seni and
                      Chinnasamy, Thirunavukkarasu and Venugopalan, Nagarajan and
                      Kandavelu, Palani and Batra-Safferling, Renu and Muthuvel,
                      Suresh Kumar},
      title        = {{I}nsights on the dynamic behavior of protein disulfide
                      isomerase in the solution environment through the {SAXS}
                      technique},
      journal      = {In Silico Pharmacology},
      volume       = {12},
      number       = {1},
      issn         = {2193-9616},
      address      = {Heidelberg [u.a.]},
      publisher    = {SpringerOpen},
      reportid     = {FZJ-2024-03003},
      pages        = {23},
      year         = {2024},
      abstract     = {The dynamic behavior of Protein Disulfide Isomerase (PDI)
                      in an aqueous solution environment under physiologically
                      active pH has been experimentally verified in this study
                      using Small Angle X-ray Scattering (SAXS) technique. The
                      structural mechanism of dimerization for full-length PDI
                      molecules and co-complex with two renowned substrates has
                      been comprehensively discussed. The structure models
                      obtained from the SAXS data of PDI purified from bovine
                      liver display behavior duality between unaccompanied-enzyme
                      and after engaged with substrates. The analysis of SAXS data
                      revealed that PDI exists as a homo-dimer in the solution
                      environment, and substrate induction provoked its
                      segregation into monomer to enable the enzyme to interact
                      systematically with incoming clients.},
      cin          = {IBI-7},
      ddc          = {570},
      cid          = {I:(DE-Juel1)IBI-7-20200312},
      pnm          = {5241 - Molecular Information Processing in Cellular Systems
                      (POF4-524)},
      pid          = {G:(DE-HGF)POF4-5241},
      typ          = {PUB:(DE-HGF)16},
      doi          = {10.1007/s40203-024-00198-0},
      url          = {https://juser.fz-juelich.de/record/1025609},
}