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@ARTICLE{Sanyasi:1025609,
author = {Sanyasi, Chandrasekar and Balakrishnan, Susmida Seni and
Chinnasamy, Thirunavukkarasu and Venugopalan, Nagarajan and
Kandavelu, Palani and Batra-Safferling, Renu and Muthuvel,
Suresh Kumar},
title = {{I}nsights on the dynamic behavior of protein disulfide
isomerase in the solution environment through the {SAXS}
technique},
journal = {In Silico Pharmacology},
volume = {12},
number = {1},
issn = {2193-9616},
address = {Heidelberg [u.a.]},
publisher = {SpringerOpen},
reportid = {FZJ-2024-03003},
pages = {23},
year = {2024},
abstract = {The dynamic behavior of Protein Disulfide Isomerase (PDI)
in an aqueous solution environment under physiologically
active pH has been experimentally verified in this study
using Small Angle X-ray Scattering (SAXS) technique. The
structural mechanism of dimerization for full-length PDI
molecules and co-complex with two renowned substrates has
been comprehensively discussed. The structure models
obtained from the SAXS data of PDI purified from bovine
liver display behavior duality between unaccompanied-enzyme
and after engaged with substrates. The analysis of SAXS data
revealed that PDI exists as a homo-dimer in the solution
environment, and substrate induction provoked its
segregation into monomer to enable the enzyme to interact
systematically with incoming clients.},
cin = {IBI-7},
ddc = {570},
cid = {I:(DE-Juel1)IBI-7-20200312},
pnm = {5241 - Molecular Information Processing in Cellular Systems
(POF4-524)},
pid = {G:(DE-HGF)POF4-5241},
typ = {PUB:(DE-HGF)16},
doi = {10.1007/s40203-024-00198-0},
url = {https://juser.fz-juelich.de/record/1025609},
}