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@INPROCEEDINGS{Saberi:1025672,
      author       = {Saberi, Amin and Wischnewski, Kevin and Jung, Kyesam and
                      Schaare, Lina and Popovych, Oleksandr and Eickhoff, Simon
                      and Valk, Sofie},
      title        = {{W}hole-brain dynamical modeling of the adolescent
                      developing brain},
      reportid     = {FZJ-2024-03061},
      year         = {2023},
      abstract     = {Regulation of cortical microcircuits is crucial for optimal
                      neural processing. Adolescence involves substantial macro-
                      and microscale changes in the brain, including maturation of
                      cortical microcircuits. Evidence from animal studies
                      suggests a calibration of cortical microcircuits and
                      excitation-to-inhibition (E-I) ratio during adolescence.
                      However, in-vivo measurement of cortical microcircuits in
                      the human developing brain is challenging, and therefore the
                      supporting in-vivo evidence on maturation of E-I ratio in
                      humans is limited. Whole-brain dynamical modeling is a
                      promising approach that enables mechanistic inferences about
                      hidden brain features, such as estimated properties of
                      cortical microcircuits and E-I ratio. Here, we used
                      whole-brain dynamical modeling to study age-related changes
                      of whole-brain model parameters during adolescence.We
                      simulated cortical activity based on a mean-field model of
                      excitatory and inhibitory neuronal ensembles in regions
                      connected based on subject-specific or group-averaged
                      structural connectomes. The fit of simulations to empirical
                      resting-state functional images of each subject was
                      evaluated based on comparison of simulated and empirical
                      functional connectivity as well as functional connectivity
                      dynamics matrices. We identified optimal model parameters
                      for each subject using covariance matrix adaptation
                      evolution strategy as well as GPU-accelerated grid search of
                      the whole parameter space. Based on the simulations
                      performed with the optimal parameters, we calculated the
                      regional E-I ratios in the simulation as their time-averaged
                      simulated excitatory firing rates. We observed
                      region-specific changes of E-I ratio with age, which was
                      decreased in parietal and frontal regions and increased in
                      occipital regions. In addition, we observed association of
                      grey-white matter contrast with E-I ratio in specifc
                      regions. Following, we aim to increase regional specificity
                      of the simulations by introducing heterogeneity in the model
                      parameters based on biological maps of receptors as well as
                      myelo- and cytoarchitecture.Overall, we present a
                      whole-brain modeling approach to estimate E-I ratio in
                      developing adolescents which revealed region-specific
                      changes of E-I ratio with age and its links to cortical
                      microstructure.},
      month         = {Oct},
      date          = {2023-10-04},
      organization  = {7th BigBrain Workshop, Reykjavík
                       (Iceland), 4 Oct 2023 - 6 Oct 2023},
      subtyp        = {After Call},
      cin          = {INM-7},
      cid          = {I:(DE-Juel1)INM-7-20090406},
      pnm          = {5252 - Brain Dysfunction and Plasticity (POF4-525) / JL
                      SMHB - Joint Lab Supercomputing and Modeling for the Human
                      Brain (JL SMHB-2021-2027)},
      pid          = {G:(DE-HGF)POF4-5252 / G:(DE-Juel1)JL SMHB-2021-2027},
      typ          = {PUB:(DE-HGF)6},
      url          = {https://juser.fz-juelich.de/record/1025672},
}