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@ARTICLE{Li:1025884,
author = {Li, Fali and Wang, Guangying and Jiang, Lin and Yao,
Dezhong and Xu, Peng and Ma, Xuntai and Dong, Debo and He,
Baoming},
title = {{D}isease-specific resting-state {EEG} network variations
in schizophrenia revealed by the contrastive machine
learning},
journal = {Brain research bulletin},
volume = {202},
issn = {0361-9230},
address = {Amsterdam [u.a.]},
publisher = {Elsevier Science},
reportid = {FZJ-2024-03169},
pages = {110744 -},
year = {2023},
abstract = {Given a multitude of genetic and environmental factors,
when investigating the variability in schizophrenia (SCZ)
and the first-degree relatives (R-SCZ), latent
disease-specific variation is usually hidden. To reliably
investigate the mechanism underlying the brain deficits from
the aspect of functional networks, we newly iterated a
framework of contrastive variational autoencoders (cVAEs)
applied in the contrasts among three groups, to disentangle
the latent resting-state network patterns specified for the
SCZ and R-SCZ. We demonstrated that the comparison in
reconstructed resting-state networks among SCZ, R-SCZ, and
healthy controls (HC) revealed network distortions of the
inner-frontal hypoconnectivity and frontal-occipital
hyperconnectivity, while the original ones illustrated no
differences. And only the classification by adopting the
reconstructed network metrics achieved satisfying
performances, as the highest accuracy of $96.80\%$ ±
$2.87\%,$ along with the precision of $95.05\%$ ± $4.28\%,$
recall of $98.18\%$ ± $3.83\%,$ and F1-score of $96.51\%$
± $2.83\%,$ was obtained. These findings consistently
verified the validity of the newly proposed framework for
the contrasts among the three groups and provided related
resting-state network evidence for illustrating the
pathological mechanism underlying the brain deficits in SCZ,
as well as facilitating the diagnosis of SCZ.},
cin = {INM-7},
ddc = {150},
cid = {I:(DE-Juel1)INM-7-20090406},
pnm = {5251 - Multilevel Brain Organization and Variability
(POF4-525)},
pid = {G:(DE-HGF)POF4-5251},
typ = {PUB:(DE-HGF)16},
pubmed = {37591404},
UT = {WOS:001063361900001},
doi = {10.1016/j.brainresbull.2023.110744},
url = {https://juser.fz-juelich.de/record/1025884},
}