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001025964 1001_ $$0P:(DE-Juel1)177730$$aBlömeke, Lara$$b0$$ufzj
001025964 245__ $$aAβ oligomers peak in early stages of Alzheimer's disease preceding tau pathology
001025964 260__ $$aHoboken, NJ$$bWiley$$c2024
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001025964 520__ $$aINTRODUCTION: Soluble amyloid beta (Aβ) oligomers have been suggested as initiating Aβ related neuropathologic change in Alzheimer’s disease (AD) but their quantitative distribution and chronological sequence within the AD continuum remain unclear.METHODS: A total of 526 participants in early clinical stages of AD and controls from a longitudinal cohort were neurobiologically classified for amyloid and tau pathology applying the AT(N) system. Aβ and tau oligomers in the quantified cerebrospinal fluid (CSF) were measured using surface-based fluorescence intensity distribution analysis (sFIDA) technology.RESULTS: Across groups, highest Aβ oligomer levels were found in A+ with subjective cognitive decline and mild cognitive impairment.Aβ oligomers were significantly higher in A+T− compared to A−T− and A+T+. APOE ε4 allele carriers showed significantly higher Aβ oligomer levels. No differences in tau oligomers were detected.DISCUSSION: The accumulation of Aβ oligomers in the CSF peaks early within the AD continuum, preceding tau pathology. Disease-modifying treatments targeting Aβ oligomers might have the highest therapeutic effect in these disease stages.
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001025964 7001_ $$0P:(DE-Juel1)190725$$aRehn, Fabian$$b1$$ufzj
001025964 7001_ $$0P:(DE-Juel1)172001$$aKraemer-Schulien, Victoria$$b2$$ufzj
001025964 7001_ $$0P:(DE-Juel1)159137$$aKutzsche, Janine$$b3$$ufzj
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001025964 7001_ $$0P:(DE-Juel1)162212$$aBujnicki, Tuyen$$b5$$ufzj
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001025964 7001_ $$0P:(DE-HGF)0$$aAltenstein, Slawek$$b13
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001025964 7001_ $$0P:(DE-HGF)0$$aLaske, Christoph$$b32
001025964 7001_ $$0P:(DE-HGF)0$$aMunk, Matthias H.$$b33
001025964 7001_ $$0P:(DE-HGF)0$$aSanzenbacher, Carolin$$b34
001025964 7001_ $$0P:(DE-HGF)0$$aSpottke, Annika$$b35
001025964 7001_ $$0P:(DE-HGF)0$$aRoy-Kluth, Nina$$b36
001025964 7001_ $$0P:(DE-HGF)0$$aHeneka, Michael T.$$b37
001025964 7001_ $$0P:(DE-HGF)0$$aBrosseron, Frederic$$b38
001025964 7001_ $$aWagner, Michael$$b39
001025964 7001_ $$0P:(DE-HGF)0$$aWolfsgruber, Steffen$$b40
001025964 7001_ $$0P:(DE-HGF)0$$aKleineidam, Luca$$b41
001025964 7001_ $$0P:(DE-HGF)0$$aStark, Melina$$b42
001025964 7001_ $$0P:(DE-HGF)0$$aSchmid, Matthias$$b43
001025964 7001_ $$0P:(DE-HGF)0$$aJessen, Frank$$b44
001025964 7001_ $$0P:(DE-Juel1)157832$$aBannach, Oliver$$b45$$eCorresponding author$$ufzj
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001025964 7001_ $$0P:(DE-Juel1)161184$$aPeters, Oliver$$b47$$eCorresponding author
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