% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@ARTICLE{Blmeke:1025964,
      author       = {Blömeke, Lara and Rehn, Fabian and Kraemer-Schulien,
                      Victoria and Kutzsche, Janine and Pils, Marlene and
                      Bujnicki, Tuyen and Lewczuk, Piotr and Kornhuber, Johannes
                      and Freiesleben, Silka D. and Schneider, Luisa-Sophie and
                      Preis, Lukas and Priller, Josef and Spruth, Eike J. and
                      Altenstein, Slawek and Lohse, Andrea and Schneider, Anja and
                      Fliessbach, Klaus and Wiltfang, Jens and Hansen, Niels and
                      Rostamzadeh, Ayda and Düzel, Emrah and Glanz, Wenzel and
                      Incesoy, Enise I. and Butryn, Michaela and Buerger,
                      Katharina and Janowitz, Daniel and Ewers, Michael and
                      Perneczky, Robert and Rauchmann, Boris-Stephan and Teipel,
                      Stefan and Kilimann, Ingo and Goerss, Doreen and Laske,
                      Christoph and Munk, Matthias H. and Sanzenbacher, Carolin
                      and Spottke, Annika and Roy-Kluth, Nina and Heneka, Michael
                      T. and Brosseron, Frederic and Wagner, Michael and
                      Wolfsgruber, Steffen and Kleineidam, Luca and Stark, Melina
                      and Schmid, Matthias and Jessen, Frank and Bannach, Oliver
                      and Willbold, Dieter and Peters, Oliver},
      title        = {{A}β oligomers peak in early stages of {A}lzheimer's
                      disease preceding tau pathology},
      journal      = {Alzheimer's $\&$ dementia / Diagnosis, assessment $\&$
                      disease monitoring},
      volume       = {16},
      number       = {2},
      issn         = {2352-8729},
      address      = {Hoboken, NJ},
      publisher    = {Wiley},
      reportid     = {FZJ-2024-03242},
      pages        = {e12589},
      year         = {2024},
      abstract     = {INTRODUCTION: Soluble amyloid beta (Aβ) oligomers have
                      been suggested as initiating Aβ related neuropathologic
                      change in Alzheimer’s disease (AD) but their quantitative
                      distribution and chronological sequence within the AD
                      continuum remain unclear.METHODS: A total of 526
                      participants in early clinical stages of AD and controls
                      from a longitudinal cohort were neurobiologically classified
                      for amyloid and tau pathology applying the AT(N) system. Aβ
                      and tau oligomers in the quantified cerebrospinal fluid
                      (CSF) were measured using surface-based fluorescence
                      intensity distribution analysis (sFIDA) technology.RESULTS:
                      Across groups, highest Aβ oligomer levels were found in A+
                      with subjective cognitive decline and mild cognitive
                      impairment.Aβ oligomers were significantly higher in A+T−
                      compared to A−T− and A+T+. APOE ε4 allele carriers
                      showed significantly higher Aβ oligomer levels. No
                      differences in tau oligomers were detected.DISCUSSION: The
                      accumulation of Aβ oligomers in the CSF peaks early within
                      the AD continuum, preceding tau pathology. Disease-modifying
                      treatments targeting Aβ oligomers might have the highest
                      therapeutic effect in these disease stages.},
      cin          = {IBI-7},
      ddc          = {610},
      cid          = {I:(DE-Juel1)IBI-7-20200312},
      pnm          = {5244 - Information Processing in Neuronal Networks
                      (POF4-524)},
      pid          = {G:(DE-HGF)POF4-5244},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {38666085},
      UT           = {WOS:001207849500001},
      doi          = {10.1002/dad2.12589},
      url          = {https://juser.fz-juelich.de/record/1025964},
}