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001025970 1001_ $$aKovalev, Kirill$$b0
001025970 245__ $$aMechanisms of inward transmembrane proton translocation
001025970 260__ $$aLondon [u.a.]$$bNature Publishing Group$$c2023
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001025970 520__ $$aProton transport is indispensable for cell life. It is believed that molecular mechanisms of proton movement through different types of proton-conducting molecules have general universal features. However, elucidation of such mechanisms is a challenge. It requires true-atomic-resolution structures of all key proton-conducting states. Here we present a comprehensive function-structure study of a light-driven bacterial inward proton pump, xenorhodopsin, from Bacillus coahuilensis in all major proton-conducting states. The structures reveal that proton translocation is based on proton wires regulated by internal gates. The wires serve as both selectivity filters and translocation pathways for protons. The cumulative results suggest a general concept of proton translocation. We demonstrate the use of serial time-resolved crystallography at a synchrotron source with sub-millisecond resolution for rhodopsin studies, opening the door for principally new applications. The results might also be of interest for optogenetics since xenorhodopsins are the only alternative tools to fire neurons.
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001025970 7001_ $$00000-0001-7422-0899$$aTsybrov, Fedor$$b1
001025970 7001_ $$aAlekseev, Alexey$$b2
001025970 7001_ $$aShevchenko, Vitaly$$b3
001025970 7001_ $$00000-0001-7945-2218$$aSoloviov, Dmytro$$b4
001025970 7001_ $$0P:(DE-HGF)0$$aSiletsky, Sergey$$b5
001025970 7001_ $$00000-0002-2617-5920$$aBourenkov, Gleb$$b6
001025970 7001_ $$0P:(DE-HGF)0$$aAgthe, Michael$$b7
001025970 7001_ $$0P:(DE-HGF)0$$aNikolova, Marina$$b8
001025970 7001_ $$00000-0001-7906-9788$$avon Stetten, David$$b9
001025970 7001_ $$0P:(DE-HGF)0$$aAstashkin, Roman$$b10
001025970 7001_ $$0P:(DE-HGF)0$$aBukhdruker, Sergey$$b11
001025970 7001_ $$00000-0001-7744-9365$$aChizhov, Igor$$b12
001025970 7001_ $$00000-0002-1919-8649$$aRoyant, Antoine$$b13
001025970 7001_ $$00000-0003-3945-3691$$aKuzmin, Alexander$$b14
001025970 7001_ $$aGushchin, Ivan$$b15
001025970 7001_ $$00000-0003-1393-0103$$aRosselli, Riccardo$$b16
001025970 7001_ $$00000-0002-9809-2059$$aRodriguez-Valera, Francisco$$b17
001025970 7001_ $$00000-0002-8812-5849$$aIlyinskiy, Nikolay$$b18
001025970 7001_ $$0P:(DE-HGF)0$$aRogachev, Andrey$$b19
001025970 7001_ $$aBorshchevskiy, Valentin$$b20
001025970 7001_ $$00000-0001-6955-7374$$aSchneider, Thomas R.$$b21
001025970 7001_ $$0P:(DE-HGF)0$$aBamberg, Ernst$$b22
001025970 7001_ $$0P:(DE-Juel1)131964$$aGordeliy, Valentin$$b23$$eCorresponding author
001025970 773__ $$0PERI:(DE-600)2131437-8$$a10.1038/s41594-023-01020-9$$gVol. 30, no. 7, p. 970 - 979$$n7$$p970 - 979$$tNature structural & molecular biology$$v30$$x1545-9993$$y2023
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