%0 Journal Article
%A Feng, Chunliang
%A Liu, Qingxia
%A Huang, Chuangbing
%A Li, Ting
%A Wang, Li
%A Liu, Feilong
%A Eickhoff, Simon B.
%A Qu, Chen
%T Common neural dysfunction of economic decision-making across psychiatric conditions
%J NeuroImage
%V 294
%@ 1053-8119
%C Orlando, Fla.
%I Academic Press
%M FZJ-2024-03393
%P 120641 -
%D 2024
%X Adaptive decision-making, which is often impaired in various psychiatric conditions, is essential for well-being. Recent evidence has indicated that decision-making capacity in multiple tasks could be accounted for by latent dimensions, enlightening the question of whether there is a common disruption of brain networks in economic decision-making across psychiatric conditions. Here, we addressed the issue by combining activation/lesion network mapping analyses with a transdiagnostic brain imaging meta-analysis. Our findings indicate that there were transdiagnostic alterations in the thalamus and ventral striatum during the decision or outcome stage of decision-making. The identified regions represent key nodes in a large-scale network, which is composed of multiple heterogeneous brain regions and plays a causal role in motivational functioning. The findings suggest that disturbances in the network associated with emotion- and reward-related processing play a key role in dysfunctions of decision‐making observed in various psychiatric conditions. This study provides the first meta-analytic evidence of common neural alterations linked to deficits in economic decision-making.
%F PUB:(DE-HGF)16
%9 Journal Article
%$ 38735423
%U <Go to ISI:>//WOS:001243564300001
%R 10.1016/j.neuroimage.2024.120641
%U https://juser.fz-juelich.de/record/1026362