TY  - JOUR
AU  - Feng, Chunliang
AU  - Liu, Qingxia
AU  - Huang, Chuangbing
AU  - Li, Ting
AU  - Wang, Li
AU  - Liu, Feilong
AU  - Eickhoff, Simon B.
AU  - Qu, Chen
TI  - Common neural dysfunction of economic decision-making across psychiatric conditions
JO  - NeuroImage
VL  - 294
SN  - 1053-8119
CY  - Orlando, Fla.
PB  - Academic Press
M1  - FZJ-2024-03393
SP  - 120641 -
PY  - 2024
AB  - Adaptive decision-making, which is often impaired in various psychiatric conditions, is essential for well-being. Recent evidence has indicated that decision-making capacity in multiple tasks could be accounted for by latent dimensions, enlightening the question of whether there is a common disruption of brain networks in economic decision-making across psychiatric conditions. Here, we addressed the issue by combining activation/lesion network mapping analyses with a transdiagnostic brain imaging meta-analysis. Our findings indicate that there were transdiagnostic alterations in the thalamus and ventral striatum during the decision or outcome stage of decision-making. The identified regions represent key nodes in a large-scale network, which is composed of multiple heterogeneous brain regions and plays a causal role in motivational functioning. The findings suggest that disturbances in the network associated with emotion- and reward-related processing play a key role in dysfunctions of decision‐making observed in various psychiatric conditions. This study provides the first meta-analytic evidence of common neural alterations linked to deficits in economic decision-making.
LB  - PUB:(DE-HGF)16
C6  - 38735423
UR  - <Go to ISI:>//WOS:001243564300001
DO  - DOI:10.1016/j.neuroimage.2024.120641
UR  - https://juser.fz-juelich.de/record/1026362
ER  -