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@ARTICLE{Serio:1026452,
      author       = {Serio, Bianca and Yilmaz, Deniz and Pritschet, Laura and
                      Grotzinger, Hannah and Jacobs, Emily G. and Eickhoff, Simon
                      B. and Valk, Sofie L.},
      title        = {{E}xploring sex-specific neuroendocrine influences on the
                      sensorimotor-association axis in single individuals},
      journal      = {bioRxiv beta},
      address      = {Cold Spring Harbor},
      publisher    = {Cold Spring Harbor Laboratory, NY},
      reportid     = {FZJ-2024-03401},
      year         = {2024},
      abstract     = {Human neuroimaging studies consistently show multimodal
                      patterns of variability along a key principle of macroscale
                      cortical organization – the sensorimotor-association (S-A)
                      axis. However, little is known about day-to-day fluctuations
                      in functional activity along this axis within an individual,
                      including sex-specific neuroendocrine factors contributing
                      to such transient changes. We leveraged data from two
                      densely sampled healthy young adults, one female and one
                      male, to investigate intra-individual daily variability
                      along the S-A axis, which we computed as our measure of
                      functional cortical organization by reducing the
                      dimensionality of functional connectivity matrices. Daily
                      variability was greatest in temporal limbic and ventral
                      prefrontal regions in both participants, and was more
                      strongly pronounced in the male subject. Next, we probed
                      local and system-level effects of steroid hormones and
                      self-reported perceived stress on functional organization.
                      Our findings revealed modest effects that differed between
                      participants, hinting at subtle –potentially
                      sex-specific– associations between neuroendocrine
                      fluctuations and intra-individual variability along the S-A
                      axis. In sum, our study points to neuroendocrine factors as
                      possible modulators of intra-individual variability in
                      functional brain organization, highlighting the need for
                      further research in larger samples.},
      cin          = {INM-7},
      ddc          = {570},
      cid          = {I:(DE-Juel1)INM-7-20090406},
      pnm          = {5251 - Multilevel Brain Organization and Variability
                      (POF4-525)},
      pid          = {G:(DE-HGF)POF4-5251},
      typ          = {PUB:(DE-HGF)25},
      doi          = {10.1101/2024.05.04.592501},
      url          = {https://juser.fz-juelich.de/record/1026452},
}