%0 Journal Article
%A Loehrer, Philipp Alexander
%A Schumacher, Wibke
%A Jost, Stefanie T.
%A Silverdale, Monty
%A Petry-Schmelzer, Jan Niklas
%A Sauerbier, Anna
%A Gronostay, Alexandra
%A Visser-Vandewalle, Veerle
%A Fink, Gereon Rudolf
%A Evans, Julian
%A Krause, Max
%A Rizos, Alexandra
%A Antonini, Angelo
%A Ashkan, Keyoumars
%A Martinez-Martin, Pablo
%A Gaser, Christian
%A Ray Chaudhuri, K.
%A Timmermann, Lars
%A Baldermann, Juan Carlos
%A Dafsari, Haidar S.
%T No evidence for an association of voxel-based morphometry with short-term non-motor outcomes in deep brain stimulation for Parkinson’s disease
%J npj Parkinson's Disease
%V 10
%N 1
%@ 2373-8057
%C London [u.a.]
%I Nature Publ. Group
%M FZJ-2024-03586
%P 91
%D 2024
%X Deep brain stimulation of the subthalamic nucleus (STN-DBS) is an established therapy in advanced Parkinson's disease (PD). Motor and non-motor outcomes, however, show considerable inter-individual variability. Preoperative morphometry-based metrics have recently received increasing attention to explain treatment effects. As evidence for the prediction of non-motor outcomes is limited, we sought to investigate the association between metrics of voxel-based morphometry and short-term non-motor outcomes following STN-DBS in this prospective open-label study. Forty-nine PD patients underwent structural MRI and a comprehensive clinical assessment at preoperative baseline and 6-month follow-up. Voxel-based morphometry was used to assess associations between cerebral volume and non-motor outcomes corrected for multiple comparisons using a permutation-based approach. We replicated existing results associating volume loss of the superior frontal cortex with subpar motor outcomes. Overall non-motor burden, however, was not significantly associated with morphometric features, limiting its use as a marker to inform patient selection and holistic preoperative counselling.
%F PUB:(DE-HGF)16
%9 Journal Article
%$ 38671017
%U <Go to ISI:>//WOS:001209748700001
%R 10.1038/s41531-024-00695-1
%U https://juser.fz-juelich.de/record/1027020