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001027020 1001_ $$00000-0002-5279-2156$$aLoehrer, Philipp Alexander$$b0$$eCorresponding author
001027020 245__ $$aNo evidence for an association of voxel-based morphometry with short-term non-motor outcomes in deep brain stimulation for Parkinson’s disease
001027020 260__ $$aLondon [u.a.]$$bNature Publ. Group$$c2024
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001027020 520__ $$aDeep brain stimulation of the subthalamic nucleus (STN-DBS) is an established therapy in advanced Parkinson's disease (PD). Motor and non-motor outcomes, however, show considerable inter-individual variability. Preoperative morphometry-based metrics have recently received increasing attention to explain treatment effects. As evidence for the prediction of non-motor outcomes is limited, we sought to investigate the association between metrics of voxel-based morphometry and short-term non-motor outcomes following STN-DBS in this prospective open-label study. Forty-nine PD patients underwent structural MRI and a comprehensive clinical assessment at preoperative baseline and 6-month follow-up. Voxel-based morphometry was used to assess associations between cerebral volume and non-motor outcomes corrected for multiple comparisons using a permutation-based approach. We replicated existing results associating volume loss of the superior frontal cortex with subpar motor outcomes. Overall non-motor burden, however, was not significantly associated with morphometric features, limiting its use as a marker to inform patient selection and holistic preoperative counselling.
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001027020 536__ $$0G:(GEPRIS)431549029$$aDFG project 431549029 - SFB 1451: Schlüsselmechanismen normaler und krankheitsbedingt gestörter motorischer Kontrolle (431549029)$$c431549029$$x2
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001027020 7001_ $$0P:(DE-HGF)0$$aSchumacher, Wibke$$b1
001027020 7001_ $$0P:(DE-HGF)0$$aJost, Stefanie T.$$b2
001027020 7001_ $$0P:(DE-HGF)0$$aSilverdale, Monty$$b3
001027020 7001_ $$00000-0003-0749-3840$$aPetry-Schmelzer, Jan Niklas$$b4
001027020 7001_ $$0P:(DE-HGF)0$$aSauerbier, Anna$$b5
001027020 7001_ $$0P:(DE-HGF)0$$aGronostay, Alexandra$$b6
001027020 7001_ $$00000-0002-5274-7929$$aVisser-Vandewalle, Veerle$$b7
001027020 7001_ $$0P:(DE-Juel1)131720$$aFink, Gereon Rudolf$$b8$$ufzj
001027020 7001_ $$0P:(DE-HGF)0$$aEvans, Julian$$b9
001027020 7001_ $$00000-0002-4355-165X$$aKrause, Max$$b10
001027020 7001_ $$0P:(DE-HGF)0$$aRizos, Alexandra$$b11
001027020 7001_ $$00000-0003-1040-2807$$aAntonini, Angelo$$b12
001027020 7001_ $$0P:(DE-HGF)0$$aAshkan, Keyoumars$$b13
001027020 7001_ $$0P:(DE-HGF)0$$aMartinez-Martin, Pablo$$b14
001027020 7001_ $$00000-0002-9940-099X$$aGaser, Christian$$b15
001027020 7001_ $$00000-0003-2815-0505$$aRay Chaudhuri, K.$$b16
001027020 7001_ $$0P:(DE-HGF)0$$aTimmermann, Lars$$b17
001027020 7001_ $$00000-0001-5851-9268$$aBaldermann, Juan Carlos$$b18
001027020 7001_ $$00000-0001-8849-4233$$aDafsari, Haidar S.$$b19
001027020 773__ $$0PERI:(DE-600)2819218-7$$a10.1038/s41531-024-00695-1$$gVol. 10, no. 1, p. 91$$n1$$p91$$tnpj Parkinson's Disease$$v10$$x2373-8057$$y2024
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