TY  - JOUR
AU  - Loehrer, Philipp Alexander
AU  - Schumacher, Wibke
AU  - Jost, Stefanie T.
AU  - Silverdale, Monty
AU  - Petry-Schmelzer, Jan Niklas
AU  - Sauerbier, Anna
AU  - Gronostay, Alexandra
AU  - Visser-Vandewalle, Veerle
AU  - Fink, Gereon Rudolf
AU  - Evans, Julian
AU  - Krause, Max
AU  - Rizos, Alexandra
AU  - Antonini, Angelo
AU  - Ashkan, Keyoumars
AU  - Martinez-Martin, Pablo
AU  - Gaser, Christian
AU  - Ray Chaudhuri, K.
AU  - Timmermann, Lars
AU  - Baldermann, Juan Carlos
AU  - Dafsari, Haidar S.
TI  - No evidence for an association of voxel-based morphometry with short-term non-motor outcomes in deep brain stimulation for Parkinson’s disease
JO  - npj Parkinson's Disease
VL  - 10
IS  - 1
SN  - 2373-8057
CY  - London [u.a.]
PB  - Nature Publ. Group
M1  - FZJ-2024-03586
SP  - 91
PY  - 2024
AB  - Deep brain stimulation of the subthalamic nucleus (STN-DBS) is an established therapy in advanced Parkinson's disease (PD). Motor and non-motor outcomes, however, show considerable inter-individual variability. Preoperative morphometry-based metrics have recently received increasing attention to explain treatment effects. As evidence for the prediction of non-motor outcomes is limited, we sought to investigate the association between metrics of voxel-based morphometry and short-term non-motor outcomes following STN-DBS in this prospective open-label study. Forty-nine PD patients underwent structural MRI and a comprehensive clinical assessment at preoperative baseline and 6-month follow-up. Voxel-based morphometry was used to assess associations between cerebral volume and non-motor outcomes corrected for multiple comparisons using a permutation-based approach. We replicated existing results associating volume loss of the superior frontal cortex with subpar motor outcomes. Overall non-motor burden, however, was not significantly associated with morphometric features, limiting its use as a marker to inform patient selection and holistic preoperative counselling.
LB  - PUB:(DE-HGF)16
C6  - 38671017
UR  - <Go to ISI:>//WOS:001209748700001
DO  - DOI:10.1038/s41531-024-00695-1
UR  - https://juser.fz-juelich.de/record/1027020
ER  -