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@ARTICLE{Loehrer:1027020,
      author       = {Loehrer, Philipp Alexander and Schumacher, Wibke and Jost,
                      Stefanie T. and Silverdale, Monty and Petry-Schmelzer, Jan
                      Niklas and Sauerbier, Anna and Gronostay, Alexandra and
                      Visser-Vandewalle, Veerle and Fink, Gereon Rudolf and Evans,
                      Julian and Krause, Max and Rizos, Alexandra and Antonini,
                      Angelo and Ashkan, Keyoumars and Martinez-Martin, Pablo and
                      Gaser, Christian and Ray Chaudhuri, K. and Timmermann, Lars
                      and Baldermann, Juan Carlos and Dafsari, Haidar S.},
      title        = {{N}o evidence for an association of voxel-based morphometry
                      with short-term non-motor outcomes in deep brain stimulation
                      for {P}arkinson’s disease},
      journal      = {npj Parkinson's Disease},
      volume       = {10},
      number       = {1},
      issn         = {2373-8057},
      address      = {London [u.a.]},
      publisher    = {Nature Publ. Group},
      reportid     = {FZJ-2024-03586},
      pages        = {91},
      year         = {2024},
      abstract     = {Deep brain stimulation of the subthalamic nucleus (STN-DBS)
                      is an established therapy in advanced Parkinson's disease
                      (PD). Motor and non-motor outcomes, however, show
                      considerable inter-individual variability. Preoperative
                      morphometry-based metrics have recently received increasing
                      attention to explain treatment effects. As evidence for the
                      prediction of non-motor outcomes is limited, we sought to
                      investigate the association between metrics of voxel-based
                      morphometry and short-term non-motor outcomes following
                      STN-DBS in this prospective open-label study. Forty-nine PD
                      patients underwent structural MRI and a comprehensive
                      clinical assessment at preoperative baseline and 6-month
                      follow-up. Voxel-based morphometry was used to assess
                      associations between cerebral volume and non-motor outcomes
                      corrected for multiple comparisons using a permutation-based
                      approach. We replicated existing results associating volume
                      loss of the superior frontal cortex with subpar motor
                      outcomes. Overall non-motor burden, however, was not
                      significantly associated with morphometric features,
                      limiting its use as a marker to inform patient selection and
                      holistic preoperative counselling.},
      cin          = {INM-3},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-3-20090406},
      pnm          = {5251 - Multilevel Brain Organization and Variability
                      (POF4-525) / SFB 1451 C07 - Neuronale Grundlagen der Bildung
                      und Unterdrückung motorischer Tics (C07) (458687122) / DFG
                      project 431549029 - SFB 1451: Schlüsselmechanismen normaler
                      und krankheitsbedingt gestörter motorischer Kontrolle
                      (431549029)},
      pid          = {G:(DE-HGF)POF4-5251 / G:(GEPRIS)458687122 /
                      G:(GEPRIS)431549029},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {38671017},
      UT           = {WOS:001209748700001},
      doi          = {10.1038/s41531-024-00695-1},
      url          = {https://juser.fz-juelich.de/record/1027020},
}