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001027028 0247_ $$2ISSN$$a1523-5866
001027028 0247_ $$2datacite_doi$$a10.34734/FZJ-2024-03594
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001027028 1001_ $$0P:(DE-HGF)0$$aNayak, Lakshmi$$b0
001027028 245__ $$aLiquid biopsy for improving diagnosis and monitoring of CNS lymphomas: A RANO review
001027028 260__ $$aOxford$$bOxford Univ. Press$$c2024
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001027028 520__ $$aBackground: The utility of liquid biopsies is well documented in several extracranial and intracranial (brain/leptomeningeal metastases, gliomas) tumors.Methods: The RANO (Response Assessment in Neuro-Oncology) group has set up a multidisciplinary Task Force to critically review the role of blood and cerebrospinal fluid (CSF)-liquid biopsy in CNS lymphomas, with a main focus on primary central nervous system lymphomas (PCNSL).Results: Several clinical applications are suggested: diagnosis of PCNSL in critical settings (elderly or frail patients, deep locations, and steroid responsiveness), definition of minimal residual disease, early indication of tumor response or relapse following treatments, and prediction of outcome.Conclusions: Thus far, no clinically validated circulating biomarkers for managing both primary and secondary CNS lymphomas exist. There is need of standardization of biofluid collection, choice of analytes, and type of technique to perform the molecular analysis. The various assays should be evaluated through well-organized central testing within clinical trials.Keywords: CSF biomarkers; MYD88 mutations; circulating tumor DNA; primary CNS lymphomas; secondary CNS lymphomas
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001027028 7001_ $$0P:(DE-HGF)0$$aBettegowda, Chetan$$b1
001027028 7001_ $$00000-0001-9635-5487$$aScherer, Florian$$b2
001027028 7001_ $$0P:(DE-Juel1)143792$$aGalldiks, Norbert$$b3
001027028 7001_ $$0P:(DE-HGF)0$$aAhluwalia, Manmeet$$b4
001027028 7001_ $$0P:(DE-HGF)0$$aBaraniskin, Alexander$$b5
001027028 7001_ $$00000-0002-6634-0927$$avon Baumgarten, Louisa$$b6
001027028 7001_ $$00000-0002-3830-7142$$aBromberg, Jacoline E C$$b7
001027028 7001_ $$0P:(DE-HGF)0$$aFerreri, Andrés J M$$b8
001027028 7001_ $$0P:(DE-HGF)0$$aGrommes, Christian$$b9
001027028 7001_ $$0P:(DE-HGF)0$$aHoang-Xuan, Khê$$b10
001027028 7001_ $$0P:(DE-HGF)0$$aKühn, Julia$$b11
001027028 7001_ $$0P:(DE-HGF)0$$aRubenstein, James L$$b12
001027028 7001_ $$0P:(DE-HGF)0$$aRudà, Roberta$$b13
001027028 7001_ $$00000-0002-1748-174X$$aWeller, Michael$$b14
001027028 7001_ $$0P:(DE-HGF)0$$aChang, Susan M$$b15
001027028 7001_ $$00000-0001-5710-5127$$avan den Bent, Martin J$$b16
001027028 7001_ $$00000-0002-0774-7700$$aWen, Patrick Y$$b17
001027028 7001_ $$00000-0002-9204-7038$$aSoffietti, Riccardo$$b18$$eCorresponding author
001027028 773__ $$0PERI:(DE-600)2094060-9$$a10.1093/neuonc/noae032$$gVol. 26, no. 6, p. 993 - 1011$$n6$$p993 - 1011$$tNeuro-Oncology$$v26$$x1522-8517$$y2024
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