% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@ARTICLE{Hu:1027030,
      author       = {Hu, Leland S. and Smits, Marion and Kaufmann, Timothy J.
                      and Knutsson, Linda and Rapalino, Otto and Galldiks, Norbert
                      and Sundgrene, Pia C. and Cha, Soonmee},
      title        = {{A}dvanced {I}maging in the {D}iagnosis and {R}esponse
                      {A}ssessment of {H}igh-{G}rade {G}lioma: {AJR} {E}xpert
                      {P}anel {N}arrative {R}eview},
      journal      = {American journal of roentgenology},
      volume       = {224},
      number       = {1},
      issn         = {0002-9580},
      address      = {Leesburg, Va.},
      publisher    = {American Roentgen Ray Society},
      reportid     = {FZJ-2024-03596},
      pages        = {AJR.23.30612},
      year         = {2025},
      note         = {Supported by NIH grants to L. S. Hu (nos.U01CA220378,
                      U01CA250481,R01CA264992, R01CA221938, and R21NS082609).},
      abstract     = {This AJR Expert Panel Narrative Review explores the current
                      status of advanced MRI and PET techniques for the
                      posttherapeutic response assessment of high-grade adult-type
                      gliomas, focusing on ongoing clinical controversies in
                      current practice. Discussed techniques that complement
                      conventional MRI and aid the differentiation of recurrent
                      tumor from posttreatment effects include DWI and
                      diffusion-tensor imaging; perfusion MRI techniques including
                      dynamic susceptibility contrast (DSC), dynamic
                      contrast-enhanced, and arterial spin labeling MRI; MR
                      spectroscopy (MRS) including assessment of
                      2-hydroxyglutarate (2HG) concentration; glucose- and amino
                      acid (AA)-based PET; and amide proton transfer imaging.
                      Updated criteria for the Response Assessment in
                      Neuro-Oncology are presented. Given the abundant supporting
                      clinical evidence, the panel supports a recommendation that
                      routine response assessment after high-grade glioma
                      treatment should include perfusion MRI, particularly given
                      the development of a consensus recommended DSC-MRI protocol.
                      Although published studies support 2HG MRS and AA PET, these
                      techniques' widespread adoption will likely require
                      increased availability (for 2HG MRS) or increased insurance
                      funding in the United States (for AA PET). The review
                      concludes with a series of consensus opinions from the
                      author panel, centered on the clinical integration of the
                      advanced imaging techniques into posttreatment surveillance
                      protocols.Keywords: PET; advanced MRI; high-grade glioma;
                      posttreatment; surveillance.},
      cin          = {INM-3},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-3-20090406},
      pnm          = {5252 - Brain Dysfunction and Plasticity (POF4-525)},
      pid          = {G:(DE-HGF)POF4-5252},
      typ          = {PUB:(DE-HGF)16},
      doi          = {10.2214/AJR.23.30612},
      url          = {https://juser.fz-juelich.de/record/1027030},
}