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@ARTICLE{Petersen:1027082,
      author       = {Petersen, Marvin and Chevalier, Céleste and Naegele, Felix
                      L. and Ingwersen, Thies and Omidvarnia, Amir and
                      Hoffstaedter, Felix and Patil, Kaustubh and Eickhoff, Simon
                      B. and Schnabel, Renate B. and Kirchhof, Paulus and Schlemm,
                      Eckhard and Cheng, Bastian and Thomalla, Götz and Jensen,
                      Märit},
      title        = {{M}apping the interplay of atrial fibrillation, brain
                      structure, and cognitive dysfunction},
      journal      = {Alzheimer's and dementia},
      volume       = {20},
      number       = {7},
      issn         = {1552-5260},
      address      = {Hoboken, NJ},
      publisher    = {Wiley},
      reportid     = {FZJ-2024-03634},
      pages        = {4512-4526},
      year         = {2024},
      note         = {This work was funded by the Deutsche Forschungsgemeinschaft
                      (DFG, German Research Foundation) –
                      Sonderforschungsbereich 936 – [grant number 178316478] –
                      C2 (B.C., G.T.) and DFG Schwerpunktprogramm 2041 – [grant
                      number 454012190] (S.B.E, G.T.).},
      abstract     = {Introduction: Atrial fibrillation (AF) is associated with
                      an elevated risk of cognitive impairment and dementia.
                      Understanding the cognitive sequelae and brain structural
                      changes associated with AF is vital for addressing ensuing
                      health care needs.Methods and results: We examined 1335
                      stroke-free individuals with AF and 2683 matched controls
                      using neuropsychological assessments and multimodal
                      neuroimaging. The analysis revealed that individuals with AF
                      exhibited deficits in executive function, processing speed,
                      and reasoning, accompanied by reduced cortical thickness,
                      elevated extracellular free-water content, and widespread
                      white matter abnormalities, indicative of small vessel
                      pathology. Notably, brain structural differences
                      statistically mediated the relationship between AF and
                      cognitive performance.Discussion: Integrating a
                      comprehensive analysis approach with extensive clinical and
                      magnetic resonance imaging data, our study highlights small
                      vessel pathology as a possible unifying link among AF,
                      cognitive decline, and abnormal brain structure. These
                      insights can inform diagnostic approaches and motivate the
                      ongoing implementation of effective therapeutic strategies.
                      Highlights We investigated neuropsychological and multimodal
                      neuroimaging data of 1335 individuals with atrial
                      fibrillation (AF) and 2683 matched controls. Our analysis
                      revealed AF-associated deficits in cognitive domains of
                      attention, executive function, processing speed, and
                      reasoning. Cognitive deficits in the AF group were
                      accompanied by structural brain alterations including
                      reduced cortical thickness and gray matter volume, alongside
                      increased extracellular free-water content as well as
                      widespread differences of white matter integrity. Structural
                      brain changes statistically mediated the link between AF and
                      cognitive performance, emphasizing the potential of
                      structural imaging markers as a diagnostic tool in
                      AF-related cognitive decline.Keywords: atrial fibrillation;
                      diffusion magnetic resonance imaging; neuroimaging;
                      neuropsychological assessment; structural magnetic resonance
                      imaging},
      cin          = {INM-7},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-7-20090406},
      pnm          = {5252 - Brain Dysfunction and Plasticity (POF4-525)},
      pid          = {G:(DE-HGF)POF4-5252},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {38837525},
      UT           = {WOS:001238724400001},
      doi          = {10.1002/alz.13870},
      url          = {https://juser.fz-juelich.de/record/1027082},
}