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@INPROCEEDINGS{Heinzel:1027705,
      author       = {Heinzel, A. and Mauler, J. and Langen, K. J. and Neumaier,
                      B. and Mottaghy, F. M. and Shah, N. J.},
      title        = {{D}ifferential correlation of the {BOLD} response to
                      different types of emotional valence processing with the
                      availability of {GABAA} receptors: {A} combined f{MRI} and
                      [11{C}]flumazenil-{PET} study},
      reportid     = {FZJ-2024-04015},
      year         = {2022},
      abstract     = {Ziel/Aim One of the core components of emotional processing
                      is the processingof emotional valence which has been studied
                      thoroughly using fMRI. Morerecently, in order to elucidate
                      the relationship to neurotransmitters, GABA levelswere
                      measured using proton magnetic resonance spectroscopy
                      (1H-MRS). Sofar only few studies addressed the relationship
                      of GABAA-receptor availabilitywith fMRI BOLD signal. In this
                      study we investigated for the first time this
                      relationshipduring different types of emotional valence
                      processing. We hypothesiseda correlation between the BOLD
                      signal and the binding potential of aGABAA receptor ligand
                      in the medial prefrontal cortex.Methodik/Methods We
                      performed a combined fMRI and [11C]flumazenil-PETstudy in 16
                      healthy subjects with emotional and neutral stimuli from the
                      InternationalAffective Picture System (IAPS). Our task
                      comprised two types of emotionalprocessing: passive viewing
                      of emotional stimuli and cognitive appraisalof these
                      stimuli. After applying a bolus infusion protocol, PET and
                      fMRI datawere simultaneously acquired using a hybrid 3T
                      MR-BrainPET.Ergebnisse/Results We found a differential
                      correlation of the BOLD signal with[11C]flumazenil binding
                      potential in the paracingulate gyrus and the frontalmedial
                      cortex. The [11C]flumazenil binding potential in the
                      paracingulate gyruscorrelated with the BOLD signal induced
                      by picture processing and pictureappraisal. In contrast, the
                      [11C]flumazenil binding potential in the frontal
                      medialcortex correlated with passive viewing of negatively
                      and positively
                      valencedpictures.Schlussfolgerungen/Conclusions Our data
                      provide the first evidence for adifferential correlation of
                      the BOLD signal and the [11C]flumazenil binding potentialfor
                      active appraisal (paracingulate gyrus) and passive viewing
                      (frontalmedial cortex) of emotional stimuli.},
      month         = {Apr},
      date          = {2022-04-27},
      organization  = {60. Jahrestagung der Deutschen
                       Gesellschaft für Nuklearmedizin,
                       Leipzig (Germany), 27 Apr 2022 - 30 Apr
                       2022},
      subtyp        = {After Call},
      cin          = {INM-5 / INM-4},
      cid          = {I:(DE-Juel1)INM-5-20090406 / I:(DE-Juel1)INM-4-20090406},
      pnm          = {5253 - Neuroimaging (POF4-525)},
      pid          = {G:(DE-HGF)POF4-5253},
      typ          = {PUB:(DE-HGF)6},
      doi          = {10.1055/s-0042-1745985},
      url          = {https://juser.fz-juelich.de/record/1027705},
}