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@INPROCEEDINGS{Schweda:1027713,
      author       = {Schweda, V. and Graf, J. and Elmenhorst, D. and Matusch, A.
                      and Ingwersen, J. and Neumaier, B. and Aktas, O. and Bauer,
                      Andreas and Kroll, T.},
      title        = {{R}egional grey-matter {A}1 adenosine receptor expression
                      in patients with early-stage {M}ultiple {S}clerosis: {A}n in
                      vivo {PET} study},
      reportid     = {FZJ-2024-04023},
      year         = {2023},
      abstract     = {Ziel/Aim Various studies indicate that cerebral adenosine
                      modulates autoimmuneand inflammatory conditions. In line,
                      experiments in rodents as well aspost-mortem investigations
                      in humans suggested that adenosine and the A1adenosine
                      receptor (A1AR), which is the most abundant adenosine
                      receptor inthe brain, plays an important role in the
                      pathogenesis of multiple sclerosis (MS).In this study, we
                      investigated the in vivo cerebral A1AR availability in
                      earlystageMS patients.Methodik/Methods Cerebral A1AR
                      availability was investigated in vivo via PETwith the
                      A1AR-specific radiotracer F-18-CPFPX in 15 early-stage MS
                      patientsbeing free of disease-specific medication, as well
                      as in 14 age- and sex-matchedhealthy controls. Regional A1AR
                      availability was determined quantitatively forgrey matter
                      volumes of interest (VOI) by equilibrium analysis and
                      comparedbetween patients and controls, between subgroups of
                      patients, and betweenpairs of VOIs located on both
                      hemispheres of the brain.Ergebnisse/Results There were no
                      global differences in A1AR availability ingrey matter
                      regions of MS patients in comparison to healthy controls nor
                      withinclinical MS subtypes. However, single brain regions
                      exhibited significant differencesin A1AR availability
                      between both hemispheres (precentral gyrus,
                      postcentralgyrus, cerebellum, presubgenual frontal cortex,
                      subgenual frontalcortex, posterior part of superior temporal
                      gyrus, anterior part of superiortemporal gyrus) in MS
                      patients.Schlussfolgerungen/Conclusions Summarizing, this
                      study shows that thereare no global alterations of A1AR
                      availability in cerebral grey matter at earlystages of MS
                      pathology. However, we observed patient-specific
                      interhemisphericdeviations of A1AR grey matter availability
                      that require further investigation.},
      month         = {Apr},
      date          = {2023-04-19},
      organization  = {61. Jahrestagung der Deutschen
                       Gesellschaft für Nuklearmedizin,
                       Leipzig (Germany), 19 Apr 2023 - 22 Apr
                       2023},
      subtyp        = {After Call},
      cin          = {INM-5 / INM-2},
      cid          = {I:(DE-Juel1)INM-5-20090406 / I:(DE-Juel1)INM-2-20090406},
      pnm          = {5253 - Neuroimaging (POF4-525)},
      pid          = {G:(DE-HGF)POF4-5253},
      typ          = {PUB:(DE-HGF)6},
      doi          = {10.1055/s-0043-1766271},
      url          = {https://juser.fz-juelich.de/record/1027713},
}