% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@ARTICLE{Kowoll:1028206,
      author       = {Kowoll, Christina M and Schumm, Leonie and Gieffers,
                      Alexandra and Lemale, Coline L and Major, Sebastian and
                      Dohmen, Christian and Fink, Gereon R and Brinker, Gerrit and
                      von Pidoll, Tilmann and Dömer, Patrick and Dreier, Jens P
                      and Hecht, Nils and Woitzik, Johannes},
      title        = {{D}uration of spreading depression is the
                      electrophysiological correlate of infarct growth in
                      malignant hemispheric stroke},
      journal      = {Journal of cerebral blood flow $\&$ metabolism},
      volume       = {44},
      number       = {12},
      issn         = {0271-678X},
      address      = {London},
      publisher    = {Sage},
      reportid     = {FZJ-2024-04401},
      pages        = {},
      year         = {2024},
      note         = {J Cereb Blood Flow Metab. 2024 Jun 20:271678X241262203. .
                      Online ahead of print J. Woitzik received research support
                      Deutsche Forschungsgemeinschaft (DFG-WO1704/1-1;
                      DFG-WO1704/1-2). A.Gieffers is funded by the Deutsche
                      Forschungsgemeinschaft (DFG-WO 1704/1-1). J.P. Dreier
                      received research support from the Deutsche
                      Forschungsgemeinschaft (DFG DR 323/10-2)},
      abstract     = {Spreading depolarizations (SD) contribute to lesion
                      progression after experimental focal cerebral ischemia while
                      such correlation has never been shown in stroke patients. In
                      this prospective, diagnostic study, we investigate the
                      association of SDs and secondary infarct progression after
                      malignant hemispheric stroke. SDs were continuously
                      monitored for 3-9 days with electrocorticography after
                      decompressive hemicraniectomy for malignant hemispheric
                      stroke. To ensure valid detection and analysis of SDs, a
                      threshold based on the electrocorticographic baseline
                      activity was calculated to identify valid
                      electrocorticographic recordings. Subsequently SD
                      characteristics were analyzed in association to infarct
                      progression based on serial MRI. Overall, 62 patients with a
                      mean stroke volume of 289.6 ± 68 cm3 were included. Valid
                      electrocorticographic recordings were found in 44/62
                      patients with a mean recording duration of 139.6 ± 26.5
                      hours and 52.5 ± 39.5 SDs per patient. Infarct progression
                      of more than $5\%$ was found in 21/44 patients. While the
                      number of SDs was similar between patients with and without
                      infarct progression, the SD-induced depression duration per
                      day was significantly longer in patients with infarct
                      progression (593.8 vs. 314.1 minutes; *p = 0.046).
                      Therefore, infarct progression is associated with a
                      prolonged SD-induced depression duration. Real-time analysis
                      of electrocorticographic recordings may identify secondary
                      stroke progression and help implementing targeted management
                      strategies.Keywords: Electrocorticography; malignant
                      hemispheric stroke; spreading depolarization; spreading
                      depression; stroke progression.},
      cin          = {INM-3},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-3-20090406},
      pnm          = {5251 - Multilevel Brain Organization and Variability
                      (POF4-525)},
      pid          = {G:(DE-HGF)POF4-5251},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {38902207},
      UT           = {WOS:001252431100001},
      doi          = {10.1177/0271678X241262203},
      url          = {https://juser.fz-juelich.de/record/1028206},
}