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| 001 | 1028206 | ||
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| 100 | 1 | _ | |a Kowoll, Christina M |0 P:(DE-HGF)0 |b 0 |e First author |
| 245 | _ | _ | |a Duration of spreading depression is the electrophysiological correlate of infarct growth in malignant hemispheric stroke |
| 260 | _ | _ | |a London |c 2024 |b Sage |
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| 500 | _ | _ | |a J Cereb Blood Flow Metab. 2024 Jun 20:271678X241262203. . Online ahead of print J. Woitzik received research support Deutsche Forschungsgemeinschaft (DFG-WO1704/1-1; DFG-WO1704/1-2). A.Gieffers is funded by the Deutsche Forschungsgemeinschaft (DFG-WO 1704/1-1). J.P. Dreier received research support from the Deutsche Forschungsgemeinschaft (DFG DR 323/10-2) |
| 520 | _ | _ | |a Spreading depolarizations (SD) contribute to lesion progression after experimental focal cerebral ischemia while such correlation has never been shown in stroke patients. In this prospective, diagnostic study, we investigate the association of SDs and secondary infarct progression after malignant hemispheric stroke. SDs were continuously monitored for 3-9 days with electrocorticography after decompressive hemicraniectomy for malignant hemispheric stroke. To ensure valid detection and analysis of SDs, a threshold based on the electrocorticographic baseline activity was calculated to identify valid electrocorticographic recordings. Subsequently SD characteristics were analyzed in association to infarct progression based on serial MRI. Overall, 62 patients with a mean stroke volume of 289.6 ± 68 cm3 were included. Valid electrocorticographic recordings were found in 44/62 patients with a mean recording duration of 139.6 ± 26.5 hours and 52.5 ± 39.5 SDs per patient. Infarct progression of more than 5% was found in 21/44 patients. While the number of SDs was similar between patients with and without infarct progression, the SD-induced depression duration per day was significantly longer in patients with infarct progression (593.8 vs. 314.1 minutes; *p = 0.046). Therefore, infarct progression is associated with a prolonged SD-induced depression duration. Real-time analysis of electrocorticographic recordings may identify secondary stroke progression and help implementing targeted management strategies.Keywords: Electrocorticography; malignant hemispheric stroke; spreading depolarization; spreading depression; stroke progression. |
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| 700 | 1 | _ | |a Schumm, Leonie |0 P:(DE-HGF)0 |b 1 |
| 700 | 1 | _ | |a Gieffers, Alexandra |0 P:(DE-HGF)0 |b 2 |
| 700 | 1 | _ | |a Lemale, Coline L |0 P:(DE-HGF)0 |b 3 |
| 700 | 1 | _ | |a Major, Sebastian |0 0000-0003-0970-1308 |b 4 |
| 700 | 1 | _ | |a Dohmen, Christian |0 P:(DE-HGF)0 |b 5 |
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| 700 | 1 | _ | |a von Pidoll, Tilmann |0 P:(DE-HGF)0 |b 8 |
| 700 | 1 | _ | |a Dömer, Patrick |0 P:(DE-HGF)0 |b 9 |
| 700 | 1 | _ | |a Dreier, Jens P |0 0000-0001-7459-2828 |b 10 |
| 700 | 1 | _ | |a Hecht, Nils |0 0000-0001-9989-649X |b 11 |
| 700 | 1 | _ | |a Woitzik, Johannes |0 P:(DE-HGF)0 |b 12 |e Corresponding author |
| 773 | _ | _ | |a 10.1177/0271678X241262203 |g p. 0271678X241262203 |0 PERI:(DE-600)2039456-1 |n 12 |p |t Journal of cerebral blood flow & metabolism |v 44 |y 2024 |x 0271-678X |
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