TY  - JOUR
AU  - Ilyinsky, Nikolay S.
AU  - Nesterov, Semen V.
AU  - Shestoperova, Elizaveta I.
AU  - Fonin, Alexander V.
AU  - Uversky, Vladimir N.
AU  - Gordeliy, Valentin I.
TI  - On the Role of Normal Aging Processes in the Onset and Pathogenesis of Diseases Associated with the Abnormal Accumulation of Protein Aggregates
JO  - Biochemistry (Moscow)
VL  - 86
IS  - 3
SN  - 0006-2979
CY  - Dordrecht [u.a.]
PB  - Springer Science + Business Media B.V
M1  - FZJ-2024-04406
SP  - 275 - 289
PY  - 2021
AB  - Aging is a prime systemic cause of various age-related diseases, in particular, proteinopathies. In fact, most diseases associated with protein misfolding are sporadic, and their incidence increases with aging. This review examines the process of protein aggregate formation, the toxicity of such aggregates, the organization of cellular systems involved in proteostasis, and the impact of protein aggregates on important cellular processes leading to proteinopathies. We also analyze how manifestations of aging (mitochondrial dysfunction, dysfunction of signaling systems, changes in the genome and epigenome) facilitate pathogenesis of various proteinopathies either directly, by increasing the propensity of key proteins for aggregation, or indirectly, through dysregulation of stress responses. Such analysis might help in outlining approaches for treating proteinopathies and extending healthy longevity.
LB  - PUB:(DE-HGF)16
C6  - 33838629
UR  - <Go to ISI:>//WOS:000629221900003
DO  - DOI:10.1134/S0006297921030056
UR  - https://juser.fz-juelich.de/record/1028212
ER  -