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@ARTICLE{Ilyinsky:1028212,
      author       = {Ilyinsky, Nikolay S. and Nesterov, Semen V. and
                      Shestoperova, Elizaveta I. and Fonin, Alexander V. and
                      Uversky, Vladimir N. and Gordeliy, Valentin I.},
      title        = {{O}n the {R}ole of {N}ormal {A}ging {P}rocesses in the
                      {O}nset and {P}athogenesis of {D}iseases {A}ssociated with
                      the {A}bnormal {A}ccumulation of {P}rotein {A}ggregates},
      journal      = {Biochemistry (Moscow)},
      volume       = {86},
      number       = {3},
      issn         = {0006-2979},
      address      = {Dordrecht [u.a.]},
      publisher    = {Springer Science + Business Media B.V},
      reportid     = {FZJ-2024-04406},
      pages        = {275 - 289},
      year         = {2021},
      abstract     = {Aging is a prime systemic cause of various age-related
                      diseases, in particular, proteinopathies. In fact, most
                      diseases associated with protein misfolding are sporadic,
                      and their incidence increases with aging. This review
                      examines the process of protein aggregate formation, the
                      toxicity of such aggregates, the organization of cellular
                      systems involved in proteostasis, and the impact of protein
                      aggregates on important cellular processes leading to
                      proteinopathies. We also analyze how manifestations of aging
                      (mitochondrial dysfunction, dysfunction of signaling
                      systems, changes in the genome and epigenome) facilitate
                      pathogenesis of various proteinopathies either directly, by
                      increasing the propensity of key proteins for aggregation,
                      or indirectly, through dysregulation of stress responses.
                      Such analysis might help in outlining approaches for
                      treating proteinopathies and extending healthy longevity.},
      cin          = {IBI-7},
      ddc          = {540},
      cid          = {I:(DE-Juel1)IBI-7-20200312},
      pnm          = {5241 - Molecular Information Processing in Cellular Systems
                      (POF4-524)},
      pid          = {G:(DE-HGF)POF4-5241},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {33838629},
      UT           = {WOS:000629221900003},
      doi          = {10.1134/S0006297921030056},
      url          = {https://juser.fz-juelich.de/record/1028212},
}