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@ARTICLE{Elberse:1028620,
      author       = {Elberse, Jorik D and Saberi, Amin and Ahmadi, Reihaneh and
                      Changizi, Monir and Bi, Hanwen and Hoffstaedter, Felix and
                      Mander, Bryce A and Eickhoff, Simon B and Tahmasian, Masoud},
      title        = {{T}he interplay between insomnia symptoms and
                      {A}lzheimer’s {D}isease across three main brain networks},
      journal      = {Sleep},
      volume       = {47},
      number       = {10},
      issn         = {0161-8105},
      address      = {Oxford},
      publisher    = {Oxford Univ. Press},
      reportid     = {FZJ-2024-04693},
      pages        = {zsae145},
      year         = {2024},
      abstract     = {Study ObjectivesInsomnia symptoms are prevalent along the
                      trajectory of Alzheimer’s disease (AD), but the
                      neurobiological underpinning of their interaction is poorly
                      understood. Here, we assessed structural and functional
                      brain measures within and between the default mode network
                      (DMN), salience network (SN), and central executive network
                      (CEN).MethodsWe selected 320 subjects from the ADNI database
                      and divided by their diagnosis: cognitively normal (CN),
                      Mild Cognitive Impairment (MCI), and AD, with and without
                      self-reported insomnia symptoms. We measured the gray matter
                      volume (GMV), structural covariance (SC), degrees centrality
                      (DC), and functional connectivity (FC), testing the effect
                      and interaction of insomnia symptoms and diagnosis on each
                      index. Subsequently, we performed a within-group linear
                      regression across each network and ROI. Finally, we
                      correlated observed abnormalities with changes in cognitive
                      and affective scores.ResultsInsomnia symptoms were
                      associated with FC alterations across all groups. The AD
                      group also demonstrated an interaction between insomnia and
                      diagnosis. Within-group analyses revealed that in CN and
                      MCI, insomnia symptoms were characterised by within-network
                      hyperconnectivity, while in AD, within- and between-network
                      hypoconnectivity was ubiquitous. SC and GMV alterations were
                      non-significant in the presence of insomnia symptoms, and DC
                      indices only showed network-level alterations in the CEN of
                      AD individuals. Abnormal FC within and between DMN and CEN
                      hubs was additionally associated with reduced cognitive
                      function across all groups, and increased depressive
                      symptoms in AD.ConclusionsWe conclude that patients with
                      clinical AD present with a unique pattern of
                      insomnia-related functional alterations, highlighting the
                      profound interaction between both conditions.},
      cin          = {INM-7},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-7-20090406},
      pnm          = {5252 - Brain Dysfunction and Plasticity (POF4-525)},
      pid          = {G:(DE-HGF)POF4-5252},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {38934787},
      UT           = {WOS:001285659400001},
      doi          = {10.1093/sleep/zsae145},
      url          = {https://juser.fz-juelich.de/record/1028620},
}