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@INPROCEEDINGS{Eickhoff:1028723,
      author       = {Eickhoff, Simon},
      title        = {{C}onfounders and caveats in connectivity research and
                      brain-based predictions},
      reportid     = {FZJ-2024-04780},
      year         = {2024},
      abstract     = {In-vivo analyses of structural, functional, and more
                      recently molecular connectivity in the human brain as well
                      as their changes in patients with neurological or
                      psychiatric disorders have opened new avenues for
                      understanding large-scale integration in the human brain and
                      its dysfunction. Moreover, combined with machine-learning
                      methods for predicting individual phenotypes from such data,
                      they open the possibility for inference on unobserved traits
                      in single-subjects. While the perspectives of these
                      approaches for clinical and neuropsychological assessment
                      are substantial, the major part of this talk will be focused
                      on several critical yet often underappreciated challenges
                      for such endeavours. These include on the one hand technical
                      and biological aspects that may undermine the validity of
                      prediction results, in particular due to the inherent
                      low-dimensional structure of biological variability. On the
                      other hand, ethical, legal, and societal aspects will
                      ultimately shape practical adaptation but need stronger
                      consideration in the development of new pipelines if these
                      are to move beyond proof-of-concept work.},
      month         = {Jun},
      date          = {2024-06-23},
      organization  = {Organization for Human Brain Mapping
                       (OHBM) Annual Meeting 2024, Seoul
                       (South Korea), 23 Jun 2024 - 27 Jun
                       2024},
      subtyp        = {Invited},
      cin          = {INM-7},
      cid          = {I:(DE-Juel1)INM-7-20090406},
      pnm          = {5251 - Multilevel Brain Organization and Variability
                      (POF4-525)},
      pid          = {G:(DE-HGF)POF4-5251},
      typ          = {PUB:(DE-HGF)6},
      url          = {https://juser.fz-juelich.de/record/1028723},
}