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@ARTICLE{Ophey:1028967,
      author       = {Ophey, Anja and Röttgen, Sinah and Pauquet, Julia and
                      Weiß, Kim-Lara and Scharfenberg, Daniel and Doppler,
                      Christopher E. J. and Seger, Aline and Hansen, Clint and
                      Fink, Gereon Rudolf and Sommerauer, Michael and Kalbe, Elke},
      title        = {{C}ognitive training and promoting a healthy lifestyle for
                      individuals with isolated {REM} sleep behavior disorder:
                      study protocol of the delayed-start randomized controlled
                      trial {C}og{T}r{A}i{L}-{RBD}},
      journal      = {Trials},
      volume       = {25},
      number       = {1},
      issn         = {1468-6708},
      address      = {London},
      publisher    = {BioMed Central},
      reportid     = {FZJ-2024-04903},
      pages        = {428},
      year         = {2024},
      abstract     = {BackgroundIsolated REM sleep behavior disorder (iRBD) is an
                      early α-synucleinopathy often accompanied by incipient
                      cognitive impairment. As executive dysfunctions predict
                      earlier phenotypic conversion from iRBD to Parkinson’s
                      disease and Lewy body dementia, cognitive training focusing
                      on executive functions could have disease-modifying effects
                      for individuals with iRBD.MethodsThe study CogTrAiL-RBD
                      investigates the short- and long-term effectiveness and the
                      feasibility and underlying neural mechanisms of a cognitive
                      training intervention for individuals with iRBD. The
                      intervention consists of a 5-week digital cognitive training
                      accompanied by a module promoting a healthy, active
                      lifestyle. In this monocentric, single-blinded,
                      delayed-start randomized controlled trial, the
                      intervention’s effectiveness will be evaluated compared to
                      an initially passive control group that receives the
                      intervention in the second, open-label phase of the study.
                      Eighty individuals with iRBD confirmed by polysomnography
                      will be consecutively recruited from the continuously
                      expanding iRBD cohort at the University Hospital Cologne.
                      The evaluation will focus on cognition and additional
                      neuropsychological and motor variables. Furthermore, the
                      study will examine the feasibility of the intervention,
                      effects on physical activity assessed by accelerometry, and
                      interrogate the intervention’s neural effects using
                      magnetic resonance imaging and polysomnography. Besides, a
                      healthy, age-matched control group (HC) will be examined at
                      the first assessment time point, enabling a cross-sectional
                      comparison between individuals with iRBD and
                      HC.DiscussionThis study will provide insights into whether
                      cognitive training and psychoeducation on a healthy, active
                      lifestyle have short- and long-term (neuro-)protective
                      effects for individuals with iRBD.},
      cin          = {INM-3},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-3-20090406},
      pnm          = {5252 - Brain Dysfunction and Plasticity (POF4-525)},
      pid          = {G:(DE-HGF)POF4-5252},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {38943191},
      UT           = {WOS:001258659800005},
      doi          = {10.1186/s13063-024-08265-9},
      url          = {https://juser.fz-juelich.de/record/1028967},
}