%0 Electronic Article
%A Saberi, Amin
%A Wischnewski, Kevin J.
%A Jung, Kyesam
%A Lotter, Leon D.
%A Schaare, H. Lina
%A Banaschewski, Tobias
%A Barker, Gareth J.
%A Bokde, Arun L. W.
%A Desrivières, Sylvane
%A Flor, Herta
%A Grigis, Antoine
%A Garavan, Hugh
%A Gowland, Penny
%A Heinz, Andreas
%A Brühl, Rüdiger
%A Martinot, Jean-Luc
%A Paillère Martinot, Marie-Laure
%A Artiges, Eric
%A Nees, Frauke
%A Papadopoulos Orfanos, Dimitri
%A Lemaitre, Herve
%A Poustka, Luise
%A Hohmann, Sarah
%A Holz, Nathalie
%A Baeuchl, Christian
%A Smolka, Michael N.
%A Vaidya, Nilakshi
%A Walter, Henrik
%A Whelan, Robert
%A Schumann, Gunter
%A Paus, Tomáš
%A Dukart, Juergen
%A Bernhardt, Boris C.
%A Popovych, Oleksandr V.
%A Eickhoff, Simon B.
%A Valk, Sofie L.
%T Adolescent maturation of cortical excitation-inhibition balance based on individualized biophysical network modeling
%J bioRxiv beta
%C Cold Spring Harbor
%I Cold Spring Harbor Laboratory, NY
%M FZJ-2024-04987
%D 2024
%X The balance of excitation and inhibition is a key functional property of cortical microcircuits which changes through the lifespan. Adolescence is considered a crucial period for the maturation of excitation-inhibition balance. This has been primarily observed in animal studies, yet human in vivo evidence on adolescent maturation of the excitation-inhibition balance at the individual level is limited. Here, we developed an individualized in vivo marker of regional excitation-inhibition balance in human adolescents, estimated using large-scale simulations of biophysical network models fitted to resting-state functional magnetic resonance imaging data from two independent cross-sectional (N = 752) and longitudinal (N = 149) cohorts. We found a widespread relative increase of inhibition in association cortices paralleled by a relative age-related increase of excitation, or lack of change, in sensorimotor areas across both datasets. This developmental pattern co-aligned with multiscale markers of sensorimotor-association differentiation. The spatial pattern of excitation-inhibition development in adolescence was robust to inter-individual variability of structural connectomes and modeling configurations. Notably, we found that alternative simulation-based markers of excitation-inhibition balance show a variable sensitivity to maturational change. Taken together, our study highlights an increase of inhibition during adolescence in association areas using cross sectional and longitudinal data, and provides a robust computational framework to estimate microcircuit maturation in vivo at the individual level.Keywords: Adolescence; Biophysical network modeling; Excitation-inhibition balance; Resting-state functional magnetic resonance imaging.
%F PUB:(DE-HGF)25
%9 Preprint
%R 10.1101/2024.06.18.599509
%U https://juser.fz-juelich.de/record/1029131