TY  - EJOUR
AU  - Saberi, Amin
AU  - Wischnewski, Kevin J.
AU  - Jung, Kyesam
AU  - Lotter, Leon D.
AU  - Schaare, H. Lina
AU  - Banaschewski, Tobias
AU  - Barker, Gareth J.
AU  - Bokde, Arun L. W.
AU  - Desrivières, Sylvane
AU  - Flor, Herta
AU  - Grigis, Antoine
AU  - Garavan, Hugh
AU  - Gowland, Penny
AU  - Heinz, Andreas
AU  - Brühl, Rüdiger
AU  - Martinot, Jean-Luc
AU  - Paillère Martinot, Marie-Laure
AU  - Artiges, Eric
AU  - Nees, Frauke
AU  - Papadopoulos Orfanos, Dimitri
AU  - Lemaitre, Herve
AU  - Poustka, Luise
AU  - Hohmann, Sarah
AU  - Holz, Nathalie
AU  - Baeuchl, Christian
AU  - Smolka, Michael N.
AU  - Vaidya, Nilakshi
AU  - Walter, Henrik
AU  - Whelan, Robert
AU  - Schumann, Gunter
AU  - Paus, Tomáš
AU  - Dukart, Juergen
AU  - Bernhardt, Boris C.
AU  - Popovych, Oleksandr V.
AU  - Eickhoff, Simon B.
AU  - Valk, Sofie L.
TI  - Adolescent maturation of cortical excitation-inhibition balance based on individualized biophysical network modeling
JO  - bioRxiv beta
CY  - Cold Spring Harbor
PB  - Cold Spring Harbor Laboratory, NY
M1  - FZJ-2024-04987
PY  - 2024
AB  - The balance of excitation and inhibition is a key functional property of cortical microcircuits which changes through the lifespan. Adolescence is considered a crucial period for the maturation of excitation-inhibition balance. This has been primarily observed in animal studies, yet human in vivo evidence on adolescent maturation of the excitation-inhibition balance at the individual level is limited. Here, we developed an individualized in vivo marker of regional excitation-inhibition balance in human adolescents, estimated using large-scale simulations of biophysical network models fitted to resting-state functional magnetic resonance imaging data from two independent cross-sectional (N = 752) and longitudinal (N = 149) cohorts. We found a widespread relative increase of inhibition in association cortices paralleled by a relative age-related increase of excitation, or lack of change, in sensorimotor areas across both datasets. This developmental pattern co-aligned with multiscale markers of sensorimotor-association differentiation. The spatial pattern of excitation-inhibition development in adolescence was robust to inter-individual variability of structural connectomes and modeling configurations. Notably, we found that alternative simulation-based markers of excitation-inhibition balance show a variable sensitivity to maturational change. Taken together, our study highlights an increase of inhibition during adolescence in association areas using cross sectional and longitudinal data, and provides a robust computational framework to estimate microcircuit maturation in vivo at the individual level.Keywords: Adolescence; Biophysical network modeling; Excitation-inhibition balance; Resting-state functional magnetic resonance imaging.
LB  - PUB:(DE-HGF)25
DO  - DOI:10.1101/2024.06.18.599509
UR  - https://juser.fz-juelich.de/record/1029131
ER  -