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@ARTICLE{Saberi:1029131,
      author       = {Saberi, Amin and Wischnewski, Kevin J. and Jung, Kyesam and
                      Lotter, Leon D. and Schaare, H. Lina and Banaschewski,
                      Tobias and Barker, Gareth J. and Bokde, Arun L. W. and
                      Desrivières, Sylvane and Flor, Herta and Grigis, Antoine
                      and Garavan, Hugh and Gowland, Penny and Heinz, Andreas and
                      Brühl, Rüdiger and Martinot, Jean-Luc and Paillère
                      Martinot, Marie-Laure and Artiges, Eric and Nees, Frauke and
                      Papadopoulos Orfanos, Dimitri and Lemaitre, Herve and
                      Poustka, Luise and Hohmann, Sarah and Holz, Nathalie and
                      Baeuchl, Christian and Smolka, Michael N. and Vaidya,
                      Nilakshi and Walter, Henrik and Whelan, Robert and Schumann,
                      Gunter and Paus, Tomáš and Dukart, Juergen and Bernhardt,
                      Boris C. and Popovych, Oleksandr V. and Eickhoff, Simon B.
                      and Valk, Sofie L.},
      title        = {{A}dolescent maturation of cortical excitation-inhibition
                      balance based on individualized biophysical network
                      modeling},
      journal      = {bioRxiv beta},
      address      = {Cold Spring Harbor},
      publisher    = {Cold Spring Harbor Laboratory, NY},
      reportid     = {FZJ-2024-04987},
      year         = {2024},
      abstract     = {The balance of excitation and inhibition is a key
                      functional property of cortical microcircuits which changes
                      through the lifespan. Adolescence is considered a crucial
                      period for the maturation of excitation-inhibition balance.
                      This has been primarily observed in animal studies, yet
                      human in vivo evidence on adolescent maturation of the
                      excitation-inhibition balance at the individual level is
                      limited. Here, we developed an individualized in vivo marker
                      of regional excitation-inhibition balance in human
                      adolescents, estimated using large-scale simulations of
                      biophysical network models fitted to resting-state
                      functional magnetic resonance imaging data from two
                      independent cross-sectional (N = 752) and longitudinal (N =
                      149) cohorts. We found a widespread relative increase of
                      inhibition in association cortices paralleled by a relative
                      age-related increase of excitation, or lack of change, in
                      sensorimotor areas across both datasets. This developmental
                      pattern co-aligned with multiscale markers of
                      sensorimotor-association differentiation. The spatial
                      pattern of excitation-inhibition development in adolescence
                      was robust to inter-individual variability of structural
                      connectomes and modeling configurations. Notably, we found
                      that alternative simulation-based markers of
                      excitation-inhibition balance show a variable sensitivity to
                      maturational change. Taken together, our study highlights an
                      increase of inhibition during adolescence in association
                      areas using cross sectional and longitudinal data, and
                      provides a robust computational framework to estimate
                      microcircuit maturation in vivo at the individual
                      level.Keywords: Adolescence; Biophysical network modeling;
                      Excitation-inhibition balance; Resting-state functional
                      magnetic resonance imaging.},
      cin          = {INM-7},
      ddc          = {570},
      cid          = {I:(DE-Juel1)INM-7-20090406},
      pnm          = {5252 - Brain Dysfunction and Plasticity (POF4-525)},
      pid          = {G:(DE-HGF)POF4-5252},
      typ          = {PUB:(DE-HGF)25},
      doi          = {10.1101/2024.06.18.599509},
      url          = {https://juser.fz-juelich.de/record/1029131},
}