Home > Publications database > Adolescent maturation of cortical excitation-inhibition balance based on individualized biophysical network modeling > print

001     1029131
005     20240723202043.0
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100 1 _ |a Saberi, Amin
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245 _ _ |a Adolescent maturation of cortical excitation-inhibition balance based on individualized biophysical network modeling
260 _ _ |a Cold Spring Harbor
|c 2024
|b Cold Spring Harbor Laboratory, NY
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520 _ _ |a The balance of excitation and inhibition is a key functional property of cortical microcircuits which changes through the lifespan. Adolescence is considered a crucial period for the maturation of excitation-inhibition balance. This has been primarily observed in animal studies, yet human in vivo evidence on adolescent maturation of the excitation-inhibition balance at the individual level is limited. Here, we developed an individualized in vivo marker of regional excitation-inhibition balance in human adolescents, estimated using large-scale simulations of biophysical network models fitted to resting-state functional magnetic resonance imaging data from two independent cross-sectional (N = 752) and longitudinal (N = 149) cohorts. We found a widespread relative increase of inhibition in association cortices paralleled by a relative age-related increase of excitation, or lack of change, in sensorimotor areas across both datasets. This developmental pattern co-aligned with multiscale markers of sensorimotor-association differentiation. The spatial pattern of excitation-inhibition development in adolescence was robust to inter-individual variability of structural connectomes and modeling configurations. Notably, we found that alternative simulation-based markers of excitation-inhibition balance show a variable sensitivity to maturational change. Taken together, our study highlights an increase of inhibition during adolescence in association areas using cross sectional and longitudinal data, and provides a robust computational framework to estimate microcircuit maturation in vivo at the individual level.Keywords: Adolescence; Biophysical network modeling; Excitation-inhibition balance; Resting-state functional magnetic resonance imaging.
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700 1 _ |a Wischnewski, Kevin J.
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700 1 _ |a Jung, Kyesam
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700 1 _ |a Lotter, Leon D.
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700 1 _ |a Schaare, H. Lina
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700 1 _ |a Banaschewski, Tobias
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700 1 _ |a Barker, Gareth J.
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700 1 _ |a Bokde, Arun L. W.
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700 1 _ |a Desrivières, Sylvane
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700 1 _ |a Flor, Herta
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700 1 _ |a Gowland, Penny
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700 1 _ |a Heinz, Andreas
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700 1 _ |a Artiges, Eric
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700 1 _ |a Nees, Frauke
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700 1 _ |a Papadopoulos Orfanos, Dimitri
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700 1 _ |a Lemaitre, Herve
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700 1 _ |a Poustka, Luise
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700 1 _ |a Hohmann, Sarah
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700 1 _ |a Holz, Nathalie
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700 1 _ |a Baeuchl, Christian
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700 1 _ |a Smolka, Michael N.
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700 1 _ |a Vaidya, Nilakshi
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700 1 _ |a Walter, Henrik
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700 1 _ |a Whelan, Robert
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700 1 _ |a Schumann, Gunter
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700 1 _ |a Dukart, Juergen
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700 1 _ |a Bernhardt, Boris C.
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700 1 _ |a Popovych, Oleksandr V.
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700 1 _ |a Eickhoff, Simon B.
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700 1 _ |a Valk, Sofie L.
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773 _ _ |a 10.1101/2024.06.18.599509
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